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RISS 인기검색어
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- 주제어 : 수정체[水晶體] (검색결과 2 건)
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백내장 수정체의 상피세포에 있어 TGF-βisoform mRNA 발현의 정량분석
목적: Transforming growth factor(TGF)-β는 백내장의 발생과 관련이 있는 것으로 알려져 있다. 백내장 수정체에서 TGF-β isoform mRNA의 발현을 정량분석하여 각각의 TGF-β isoform과 백내장 발생의 연관성을 알아보고자 하였다. 방법: 전체 30명, 30안에서 추출한 수정체상피세포조직을 이용하여 real-time SYBR Green polymerase chain reaction으로 TGF-β1, β2와 β3 mRNA의 발현을 정량하여 백내장의 종류(노인성 25안, 초로성 5안)와 당뇨병의 유무(당뇨 17안, 비당뇨 13안)에 따라서 비교 분석하였다. 결과: TGF-β3 mRNA는 30안 모두에서, TGF-β1 mRNA는 당뇨 노인성 백내장 1 안을 제외한 29안(96.7%)에서, TGF-β mRNA는 9안(당뇨 노인성 3/14안, 21.4%; 비당뇨 노인성 2/11안, 18.2%; 당뇨 초로성 2/3안, 66.7%; 비당뇨 초로성 2/2안, 100%)에서 발현되었다. TGF-β1 mRNA의 발현양은 당뇨 노인성 백내장에서 비당뇨 노인성 백내장과 비교하여 유의하게 적었다(P=O.056). 결론: TGF-β는 백내장의 발생과 연관이 있으며, TGF-β2는 초로성보다는 노인성 백내장에서, TGF-β1은 노인성 백내장에 있어 당뇨가 있는 경우에 더욱 중요한 의미를 갖는 듯 하다 Objectives: Transforming growth factor (TGF)-0 has been accepted to be associated with cataractogenesis. I quantitated the mRNA expression of TGF-0 isoforms in cataractous crystalline lens to determine the effect of the isoforms on cataractogenesis. Methods: With lens epithelial cells of total thirty eyes in thirty patients, mRNA expression of TGF-D1, D2 and )33 were quantitated by real-time SYBR Green polymerase chain reaction and the results were compared according to types of cataract (senile, 25 eyes vs. presenile, 5 eyes) and presence of diabetus mellitus (diabetic, 17 eyes vs. non-diabetic, 13 eyes). Results: Each isoforms mRNA of TGF-0 were expressed; TGF-03 in all thirty eyes, TGF-01 in 29 eyes (96.7%) except one diabetic senile cataract and TGF-02 in 9 eyes (3/14 eyes of diabetic senile, 21.4%; 2/11 eyes of non-diabetic senile, 18.2%; 2/3 eyes of dabetic presenile, 66.7%; 2/2 eyes of non-diabetic presenile, 100%). The amount of TGF-Dl mRNA expression was significantly low the diabetic senile cataract compared to the non-diabetic senile cataract (P = 0.056). Conclusions: TGF-D would be associated with cataractogenesis. TGF-02 might be more meaningful in the senile cataract than in the presenile and TGF-01 in the diabetic condition of the senile cataract than in the non-diabetic.
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水晶體 摘出術로 인하여 發生된 前房出血에 對한 統計學的 硏究
The author clinicostatistically studied 49 eyes showing postoperative hyphema out of 277 eyes of 241 patients which had received the lens extraction during the period of January 1, 1978 to August 31, 1981, at the Department of Ophthalmology, Chosun University Hospital. And the results given from the study were as below : 1. Among 241 patients of the lens extraction, the male to female ratio was 1:1.3. But the ratio of hyphema was almostly even. 2. Cataract was the most prevalent in the age group of 60 to 79(55.2% or 153 eyes) and the least prevalent in the age groups below 19 and above 80(6.8% or 19 eyes with the two groups combined). Hyphema was the most frequent in the age group of 20 to 39(34.5% or 10 eyes), followed by the age group of 40 to 59 (18.4 % or 14 eyes). 3. Cataract was distributed evenly between right and left eyes. But hyphema more frequently appeared in the right eye. 4. The most common type of cataract was the senile cataract (75.8% or 210 eyes). Hyphema was the most frequent during or after the surgery of the juvenile cataract (41.7% or 10 eyes), followed by the complicated cataract (30.0% or 6 eyes). 5. Intracapsular lens extraction (81.6% or 226 eyes) was more frequently performed than extracapsular lens extraction (18.4% or 51 eyes). Hyphema, however, showed no significant difference between intracapsular lens extraction and extracapsular lens extraction. 6. Cataract was more common in the rural area than the urban area. Hyphema was evenly developed between rural and urban areas. 7. Among the patients with hyphema, such systemic diseases were found as pulmonary tuberculosis (10.2% or 5 eyes), bronchiectasis (8.1% or 4 eyes), diabetes mellitus (6.1% or 3 eyes) and hypertension(6.1% or 3 eyes). 8. Hyphema mainly appeared during the period of the sixth to the tenth postoperative days (57.1 % or 28 eyes). 9. Mild and moderate hyphemas (75.5% or 37 eyes) were common. Hyphema disappeared within six days in most cases(83.7'36 or 41 eyes). 10. The most frequent cause of hyphema was unknown etiology(53.1% or 26 eyes), followed by removal of corneoscleral sutures (20.4% or 10 eyes).
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