황칠나무 잎 열수추출물의 Streptozotocin에 의해 유도된 당뇨 흰쥐에서의 항당뇨 효과

김민재 경상국립대학교 보건대학원 2021 국내석사

Dendropanax morbifera Lev. (D. morbifera) is a species of native tree that is widely distributed in the southern parts of Korea including Jeju island. Since ancient times, leaves, stems and roots of the plant have been used as folk remedies to treat dermal complications and other infectious diseases. The present study was conducted to investigate the diabetes treatment effect of the plant hot water extracts (DMWE) using streptozotocin-induced diabetes in rats. In this study, thirty male 5-week-old Sprague-Dawley rats were used. The rats were divided into six groups of five rats per treatment group and administered for 4 weeks. The treatment group were normal control rats received saline (NC), diabetic control rats received saline (DC), diabetic rats treated with 500 mg/kg body weight (BW) of metformin (DT), diabetic rats treated with 50 (DM-50), 100 (DM-100) and 200 mg/kg BW (DM-200) of DMWE. After 14 days of administration of DMWEs, the BW of all groups treated with DMWEs increased significantly compared to that of DC (P<0.05), however, the BW of DM-100 and DM-200 showed no significant difference compared to that of DT. Blood sugar levels in DT and DM-200 decreased below 200 mg/dL at 3 weeks after administration of DMWEs, and at 4 weeks after treatment, blood glucose levels in DT, DM-100 and DM-200 decreased within the normal range. At 4 weeks after treatment of DMWE, the glycated hemoglobin (HbA1c) concentrations in all groups administered with DMWEs showed no significant difference compared to those of NC and DT. The HbA1c concentrations of DM-100 and DM-200 showed significant reduction compared with that of DC (P<0.05). In blood biochemical parameters, the levels of AST, ALT and BUN in DM-100 and DM-200 showed no significant difference compared to those in NC and DT, however, significant differences compared to that of DC (P<0.05). From the above results, DMWEs have been identified to be effective in the treatment of diabetes.

코로나19 발생 및 유행정도가 경남주민의 건강행태 및 우울감에 미치는 영향

서영미 경상국립대학교 보건대학원 2023 국내석사

Objectives: This study aims to investigate the influence factors by examining the relationship between the occurrence and prevalence of COVID-19 on the health behavior (smoking, drinking, physical activity) and depression of Gyeongnam residents using the natural test situation of COVID-19. Methods: This study was analyzed using raw data from the Gyeongsangnam-do Community Health Survey. A total of 35,880 people (17,942 people in 2019, 17,938 people in 2020) were used for the analysis, and all data were analyzed using SPSS 25.0. The effect of COVID-19 on the health behavior and depression of Gyeongnam-do residents was investigated by dividing it into Before and after COVID-19 outbreak and prevalence rates. General characteristics were investigated through descriptive statistical analysis, and changes in health behavior and depression in 2019-2020 were analyzed using t-test and χ² test. Multiple logistic regression analysis was used to investigate the correlation between changes in health behavior and depression and the occurrence of COVID-19 in Gyeongnam-do residents. In addition, through multilevel logistic regression analysis, regions with a high incidence rate and regions with a low incidence rate were classified to check whether there were differences in health behavior and depression between regions. All statistical significance levels were based on p<0.05. Results: Comparison results before and after the outbreak of COVID-19, The rate of smoking cessation attempts significantly decreased after the outbreak of COVID-19 compared to before the outbreak (p<0.001). The monthly drinking rate decreased after the outbreak of COVID-19 (p<0.001). However, the high-risk drinking rate increased after the outbreak of COVID-19 (p<0.001). The rate of walking practice increased after the outbreak of COVID-19 (p<0.001). As for the rate of experiencing depression, the rate of experiencing depression after the outbreak of COVID-19 increased (p<0.001). The prevalence of depressive symptoms also increased after the onset of COVID-19 (p=0.001). As a result of comparing regions by the difference in the incidence of COVID-19, the monthly drinking rate was higher in regions with a large number of confirmed cases than in regions with rare occurrences (p=0.017). As for the experience rate of depression, the rate of experiencing depression was higher in the area with a high incidence than the area with a rare occurrence (p<0.001), and the prevalence of depression was also higher in the area with a high incidence (p<0.001). Conclusion: This study shows that the occurrence of COVID-19 affects the health behavior and depression of residents in Gyeongnam, and there is a difference in health behavior and depression between regions according to the incidence of COVID-19.

특수학교 보건교사의 경험

김인영 경상국립대학교 보건대학원 2021 국내석사

Purpose : This study attempted to provide basic data for providing information on health care for disabled students and improving the quality of health care performance by exploring subjective experiences of health teachers in special schools. Methods : The subjects of this study were 11 people who have worked as health teachers at special schools for more than one year in the last three years. Individual in-depth interviews were conducted from December 2020 to January 2021, using semi-structured questionnaires in unstructured and open form for data collection. The collected data were analyzed using the content analysis method proposed by Elo & Kyngäs(2008). Result : The experience of health teachers at special schools were derived as 18 topical words, which were categorized into 6 themes through categorization work. 'Attachment after special school work', 'Health Care for Students with Disabilities in Need of Careful and Various Care', 'Pity for lack of legal basis', 'Ambivalence felt by taking care of students with disabilities', 'Health teachers competence needed to care for disabled students', and 'Unmet Needs for Health Care for Students with Disabilities'. Conclusion : As a result of this study, health teachers at special schools carry out various health care tasks. This includes providing, managing and consulting direct health care services related to the health care of disabled students, linking and supporting, and health education. In order to improve the quality of health care performance for student with disabilities, parents, school managers, and other faculty members should be involved along with teachers who actually perform the care. It is also believed that the government needs to listen to the needs of school workers and seek to find solutions to improve the difficulties associated with health care for disabled students.

황칠나무 잎 열수추출물의 고지방 식이로 유발된 고지혈증 흰쥐에서의 항고지혈증 효과

강예진 경상국립대학교 보건대학원 2021 국내석사

최근, 식생활의 서구화와 지방 및 가공식품의 소비가 증가함에 따라, 체내에 지방이 과잉 축적되어 생체 내의 에너지 대사에 직접적으로 영향을 주어 열량소비 저하, 지방산화 억제 및 혈액 내 유리지방산 과잉, 혈중 지질과산화 촉진, 중성지방 증가, 당대사 이상, 인슐린 분비와 감수성 약화 등과 같이, 생체 내 대사산물의 생성과 기능에 이상을 초래하고 있다 [19, 39]. 이로 인해 심장질환 등의 각종 성인병 및 만성 질환이 꾸준히 증가하고 있다 [13]. 지질을 낮추는데 효과적인 많은 합성약제들이 판매되고 있으나, 이러한 약제들은 심장질환, 뇌졸중, 체중 저하, 저지질혈증, 저혈당증, 근육통, 근육 손상, 간 손상, 기타 혈관질환 유발 등과 같은 부작용과 관련성이 있는 것으로 알려져 있다 [9, 54]. 최근에는 기존 고지혈증 치료제를 대체하기 위해서, 천연물로부터 부작용이 없고 안전한 고지혈증 치료 약물을 탐색하기 위한 연구들이 활발하게 진행되고 있다 [10, 11, 22, 27, 35, 36]. 본 연구에서는 다양한 효능을 갖고 있는 황칠나무 잎의 열수추출물을 이용하여 고지방 식이를 섭취시켜 고지혈증을 유발시킨 흰쥐에서 고지혈증 치료효과를 확인하였다. 황칠나무 잎 열수 추출물이 고지혈증 치료에 적용할 수 있는 기능성 물질로 확인되었다.

효소 가수분해한 황칠나무 잎 추출물의 마우스에 대한 항스트레스 효과

권송주 경상국립대학교 보건대학원 2022 국내석사

Dendropanax morbifera Lev. (D. morbifera) is a species of a native tree that is widely distributed in the southern parts of Korea, including Hadong county, Gyeongsangnam-do, Korea. From a long time ago, leaves, stems and roots of the plant have been used as folk remedies to treat dermal complications and other infectious diseases. The present study investigated the anti-stress effect of the enzymatic hydrolyzed D. morbifera leaf extracts (EHDM) in restraint stress-induced ICR mice. The EHDM doubled the content of γ-aminobutylic acid through enzymatic hydrolysis. In this study, fifty male 5-week-old ICR mice were used. The mice were divided into five groups of ten mice per treatment group and administered for 2 weeks. The treatment groups were normal control mice received distilled water (NC), stress-induced control mice received distilled water (PC), stress-induced mice administered with 50 (EHDM-50), 100 (EHDM-100) and 200 mg/kg BW (EHDM-200) of EHDM. After 2 weeks of administration of EHDMs, the BW of EHDM-100 and EHDM-200 significantly increased compared to that of PC (P<0.05), and the BW of EHDM-200 showed no significant difference compared to that of NC. After EHDM administration, blood glucose levels in EHDM-100 and EHDM-200 were significantly decreased compared to that in PC at 7 and 14 days (P<0.05), and there were no significant differences between EHDM-100, EHDM-200, and NC. In serum cortisol concentrations, EHDM-100 and EHDM 200 were significantly decreased compared to PC (P<0.05). From the above results, EHDM at the concentration of 100 mg/kg BW has been identified to be effective in the stress relief.

제브라피시 배아에 대한 미세플라스틱과 플라스틱 첨가제의 혼합 독성 영향 연구

김고은 경상국립대학교 보건대학원 2022 국내석사

일 지역 금연지원센터에 등록된 중소규모 사업장 남성 근로자의 6개월 금연 성공 요인

류일화 경상국립대학교 보건대학원 2021 국내석사

Objectives: This study aims to identify the factors influenced by examining relation between their sociodemographic characteristics, companies characteristics, smoking-related characteristics, supporters for quitting smoking, and smoking-related psychology. Methods: The subjects of this study were smoking men-workers who had got the visiting services at the G smoking cessation center to stop smoking from January 2018 to December 2020. Total number of the participants was 767 and they were divided into two groups by the size of workplace located in Gyeongsangnam-do: one consisted of 159 workers (20.7%) from 33 small business with less than 50 employees; the other was made up of 608 workers (79.3%) from 42 medium-sized business with from 50 to 300 employees. This study had used the methods such as sociodemographic characteristics (age, educational level, drinking, exercising, chronic illness), smoking-related characteristics (daily average of smoking, smoking duration, nicotine dependence, Attempt to quit smoking), smoking-related psychology(importance of smoking cessation, confidence in smoking cessation, Readiness of smoking cessation), companies characteristics, (the classification of companies, the size of companies, and the will for smoking cessation program of the manager), supporters for quitting smoking( family, co-workers, friends/others.). By using SPSS version 25.0 statistics program, this study analyzed frequency, mean and standard deviation and conducted chi-square test and multiple logistic regression based on the collected data. The outcome was tested by using odds ratio, 95% confidence interval and p-value. The odds ratio greater than 1 means successful smoking cessation and the statistical significance level was based on p < 0.05. Results: The men-workers in small and medium-sized business had a success rate of 20.2% for smoking cessation for 6 months. With multiple logistic regression, the factors causing the differences in the success rate for 6 months of the workers were as follows. The odds ratio of the age under 29, 40~49 was 0.10(95% CI, 0.03-0.29) and 0.43(95% CI, 0.24-0.76) in comparison to the age upper 50. Regarding the average amount of smoking per day, the odds ratio of the group of 11-20 and that of the group more than 21 was 0.52(95% CI, 0.34-0.80) and 0.46(95% CI, 0.24-0.90) respectively, when compared to the group of 1-10. Regarding the supporters for quitting smoking, the odds ratio of group with spouse and other family is 1.99(95% CI, 1.18-3.34) in comparison to the group with no one. Conclusion: This study shows that the chance of success for smoking cessation for 6 months is higher when the subjects have spouses and other family supporters for quitting smoking. And it also shows that the less they smoke a day and the older they are, the more likely it is to succeed in quitting smoking.

일부 중소병원 행정직원의 코로나19 유행에 따른 이직의도와 영향요인 : 근무환경, 직무스트레스, 신체적 피로 및 직무만족을 중심으로

박진숙 경상국립대학교 보건대학원 2022 국내석사

Purpose: This study aims to provide primary data for improvement by identifying the working environment, job stress, physical fatigue, and job satisfaction levels for administrative staff working at medical institutions in the COVID-19 pandemic situation and examining factors affecting job turnover. Methods: In this study, six medical institutions designated as screening and relief hospitals with more than 100 beds and less than 300 beds in the J city area of ​​Gyeongnam Province, except for medical personnel (doctors and nurses) who directly participate in patient treatment, were hospital workers who were working as administrative personnel. Data were collected by using a questionnaire. During the collection period, from October 20, 2021, to October 23, 2021, all 140 copies were collected for 140 people. The collected data were analyzed using SPSS/WIN 23.0 program, and real number and percentage, mean and standard deviation, independent t-test, ANOVA, scheffe test, Pearson correlation coefficients, and hierarchical rarity analysis were used. Results: 1. In terms of demographic, job-related, and COVID-19 work-related characteristics of the participants, there were 111 women (79.3%), the average age was 35.06±10.33 years, 73 'unmarried' status (52.1%). As for the education level, 87 people (62.1%) had ‘college or less’, 65 people (46.4%) from the 'general affairs department', working experience averaged 8.83±9.39 years, and 116 people were 'employee/manager' in the job position. Seventy-seven people replied that the salary level was ‘normal’ (55.0%), 58 people were ‘dissatisfied’ (41.4%), 131 people were ‘regular workers’ (93.6%), and 74 people did not exercise regularly (52.9%). Regarding the health status of the workers compared to the pre-COVID-19 situation, 85 people replied that they were ‘healthy’ (60.7%), 76 people said ‘yes’ to have experienced turnover (54.3%), 69 people have had ‘no contact’ with suspected COVID-19 patients (49.3%) while 55 people have had '1-5 times' of experience (39.3%). Among all participants, 115 people (82.1%) said 'no' for the quarantine experience. Also, as a result of multiple response analyses for increased work after the outbreak of COVID-19, 112 people have gone through ‘Fever check’ (80.0%). 2. Looking at the participants’ working environment, job stress, physical fatigue, job satisfaction, and turnover intention, the average score of working environment was 3.16±0.50 out of 5, and 'institutional support' among the sub-factors was the lowest at 2.63±0.67. For job stress, the average score was 3.28±0.53 out of 5, and 'risk of infection' was the highest with 3.51±0.79 points. The average score for physical fatigue was 3.01±0.65 out of 5, and in particular, ‘difficulty due to new roles and demands’ scored 3.16±0.68 points, which corresponded to factors with high physical fatigue. The average scores of job satisfaction and turnover intention were 2.84±0.70 and 3.04±0.76 out of 5, respectivley. 3. As a result of examining the differences in the working environment, job stress, physical fatigue, job satisfaction, turnover intention according to the characteristics of the participants, it was found that if they were satisfied with the salary level, they perceived the working environment as good. However, those who categorized their salary level as 'normal' and 'dissatisfaction' were bound to have higher job stress, physical fatigue, and job satisfaction. Turnover intention differed according to which rank they belonged to; ‘employees and managers’ had higher turnover intention than ‘chief’ and ‘agent level or higher,’ while ‘discontent’ had higher turnover intention than ‘satisfaction’ and ‘normal’ in monthly salary level. 4. As a result of analyzing the correlation between the participants’ working environment, job stress, physical fatigue, job satisfaction, turnover intention, the turnover intention had a negative correlation with the working environment (r=-.63, p<.001) and job satisfaction (r=-.58, p<.001), and positive correlation with job stress (r= .30, p<.001) and physical fatigue (r= .49, p<.001). 5. As a result of hierarchical regression analysis to find out the effect of the subject's work environment, job stress, physical fatigue, and job satisfaction on turnover intention, the variable that had a significant effect on turnover intention was physical fatigue (ß=.31. p<.001), dissatisfaction with salary level (ß=.26, p<.001), working environment (ß=-.24, p=.003), job satisfaction (ß=-.23, p=.001) in order. In other words, the higher the physical fatigue, the higher the dissatisfaction with the salary level, the worse the working environment, and the lower the job satisfaction, the higher the turnover intention. The total explanatory power of these variables explaining turnover intention was 60.9% (F=22.46, p<.001, R2=.609, Adj-R2=.582). Conclusion: In this study, the factors affecting the turnover intention of the administrative staff of small and medium hospitals in the context of COVID-19 in this study were physical fatigue, satisfaction with salary level, working environment, and job satisfaction. The increased workload of hospital administrative staff concerning COVID-19 patients increases physical fatigue, which is expected to increase turnover intention. In addition, dissatisfaction with salary level, working environment, and the job was found to be a factor that increased turnover intention. Therefore, it is necessary to change administrative staff’s salary level and compensation system in small and medium-sized hospitals.