하악골 시상분할절골술에 의한 후방이동후 설골과 혀의 위치에 변화에 관한 연구

김상천 한림대학교 1992 국내석사

The position of the hyoid bone relative to the cranial base and the mandibe has been of interest especially as an indicator of the tongue posture and function. Surgical procedures that alter the size of the oral cavity inevitably affect the tongue. But.little was known about the adaptation of the tongue and hyoid bone to an altered oral environment following surgical setback of the mandible. The purpose of this study was to evaluate changes in tongue and hyoid bone and the relationship between tongue posture and hyoid position following surgical set-back of the mandible. Following mandiblar surgical set-back by rigid fixation with screws, author analysed the posture changes of the tongue and hyoid bone in 25 cases. The results are as follows; 1. Changes of Tongue posture. A. The distance from posterior pharyngeal wall to tongue was decreased 0.34mm at immediate postsurgical period and increased 0.31mm at postoperative 1 year. B. The distance from palatal plane to tongue was decreased 0.54mm at immediate postsurgical period and increased 0.51mm at postoperative 1 year. 2. Changes of hyoid bone A. The distance from posterior pharyngeal wall to hyoid bone was decreased 0.69mm at the immediate postsurgical periods and increased 0.21mm at postoperative 1 year. B. The distance from genial tubercle to hyoid bone was significantly decreased 5.59mm at the immediate postsurgical periods and increased 0.93mm at postoperative 1 year. C. The distance from palatal plan to hyoid bone was significently increased 3.43mm at immediate postsurgical periods and decreased 0.19mm at postoperative 1 year. d. The angular dimensional changes of LHA-BaN and LAH-PP was increased each 3.37, 3.81 degree at the immediate postsurgical periods and decreased each 0.28, 0.47 degree at postoperative 1 year. 3. The hyoid bone and tongue was moved postero-inferior direction at the immediate postsurgical periods and had move toward its preoperative position as the suprahyiod musculature adapts to the new condition.

박테리아 기원의 생화학 물질이 구강암세포주의 증식에 미치는 영향

채창훈 翰林大學校 2007 국내박사

A chemical analog of naturally occurring alkylresorcinols 4-hexylresorcinol (4-HR) was demonstrated to exert an inhibitory effect on the growth and dedifferentiation of squamous cell carcinoma in vitro and in vivo. After added to cultured SCC-9 cells (in vitro) in final concentrations 0.15-0.17 uM, 4-HR significantly suppressed the tumor cell proliferation with dose-dependent inhibition of respiratory activity and caused prominent morphological changes (e.g. size reduction, rounding, appearance of refractility). Noteworthy, the effect of 4-HR was followed by increasing the level of intracellular calcium level as proved by confocal laser scanning microscopy studies with the use of a Ca-sensitive fluo-4 AM dye. In vivo tests with the use of xenograft model of SSC-9 implantation in nude mice showed that the tumor mass was substantially and dose-dependently reduced in the group of animals injected intraperitoneally with 4-HR. Immunochemical analysis with the use of specific antibodies revealed the increased expression of cytokeratin, a well-known marker of epithelial cell differentiation, and the reduced expression of Ki67, a cellular proliferation marker, in tumors after 4-HR administration as compared to the control. Taken together, the data obtained in vitro and in vivo test gives an evidence of 4-HR action on carcinoma cells due to changes of their metabolic activity, growth inhibition, and developmental program.

Cyclosporin A의 투여가 정상 섬유아 세포주에서 FGF-5와 FGF-7의 발현에 미치는 영향에 관한 연구

조남성 翰林大學校 2004 국내박사

The gingival hyperplasia induced by cyclosporin A was a common complication in organ transplantation patients. In previous study, FGF-5 and FGF-7 were over-expressed in the gingival hyperplasia and FGF-5 was a potent mitogen for human fibroblasts. However, it is unclear whether cyclosporin A can induce FGF-5 or FGF-7 in cultured fibroblasts and whether it is directly associated with the proliferation of fibroblasts. Normal dermal fibroblast was cultured with cyclosporin A. The effect of cyclosporin A on the expression of FGF-5 and FGF-7 was analyzed in 2, 4, 8, 24 hours after administration with RT-PCR. The cell count was done with hemocytometer. For the evaluation of the effect of FGF-5, FGF-5 antibody was given with cyclosporin A and it was evaluated with MTT assay. In results, cyclosporin A could increase the expression of FGF-5 and FGF-7. The expression of FGF-5 was dependent on time and concentration of cyclosporin A. However, FGF-7 was consistently up-regulated. The proliferation of fibroblasts was dependent on the concentration of cyclosporin A. The number of fibroblast was positively correlated with the expression of FGF-5 at 8 and 24 hours (P<0.05). The proliferation of fibroblasts induced by cyclosporin A was significantly inhibited by FGF-5 antibody (P<0.001). In conclusion, FGF-5 was a potent mitogen for human fibroblasts and its expression was induced by cyclosporin A. Although FGF-7 was also induced, its expression was not associated with the proliferation of fibroblasts. Thus, the gingival hyperplasia in the immunosuppressed patients seemed to be occurred via the action of FGF-5.

측두하악장애 환자의 임상 및 정신 생리학적 분석

김상봉 한림대학교 1991 국내석사

This study was directed to clinical and pscychosomatic analysis in the temporomandibular disorder patients and control group, using various test batteries, such as temporomandibular disorder chart, social readjustment rating scale, coping strategies of Weisman, a global assessment of recent stress scale of Linn, Zung's self-rating scale of depression and MMPI. 67 subjscts(33 of TMD patients and 34 of controls) who visited our dept, were evaluated and analyzed through SPSS program. The obtained results were as follows; 1. T.M.D. patients included more female than male and mean age was below 20 years old, education level was generally low and had many students & housewives. 2. A half of the T.M.D. patients had combined diseases, two-third had predpitating factor and all had two or three type of clinical symptom. 3. In T.M.D. patients there were no significant difference in psychosomatic analysis whether they had any precipitating factor or not. 4. In the T.M.D. patients, the group with combined diseases seemed to be more sensitive to interpersonal relationship, illness and to have higher tendency to depression than the group without combined diseases. 5. T.M.D. patients seemed to have more stress in SRRS, less responsive to the pressure from financial difficulties and unfamiliar with the three coping strategies, namely shared concern, redefinition, and acting-out.

골격성 제Ⅲ급 부정교합 환자의 2단계 치료후 경과에 대한 임상적 연구

趙允珠 翰林大學校 大學院 1999 국내석사

The purpose of this study was to evaluate the result after 2-phase surgical-orthodontic treatment without preoperative orthodontic treatment for the skeletal CI ￥² malocclusion patient and to obtain an adequate protocol on the bases of this result. This retrospective study of ten patients who underwent 2-phase treatment were done to evaluate 1) the surgical stability and re]apse pattern 2) the facial esthetics 3) the TMJ Problem 4) the total time of the treatment. Results were followed : 1) The horizontal relapse of the mandible was 26.8% and didn't show significant differences compared to the conventional 3-phase treatment. But, it was considered that this amount of relapse was the sum of true relapse and autoratation of mandible due to decreased vertical dimension during orthodontic treatment. 2) It was estimated that there's no difference on the ratio of anterior facial height between the subjects and the normal patients. On the horizontal analysis, the mandible of the subjects was located more anteriorly than that of the normal patients This result showed that there was a need for the accurate preoperative estheticevaluation and the additional methods for reducing the relapse due to the occlusal interference. 3) Wide variation was noted on the TMJ symptoms of the subjects, however, it was estimated that there's no significant differences of symptoms compared to that of the conventional 3-phase treatment on literatures. 4) The average of the overall period of treatment was 20.8 months and we obtained reduction of the treatment time compaired to 3-phase treatment on many literatures. Most of the results of this study were similar to the findings of the 3-phase treatment (preoperative orthodontic-orthognathic surgery-postoperative orthodontic), but total time of the treatment was shorter in patients with 2-phase treatment tha in those with the conventional 3-phase treatment. With 2-phase treatment we experienced many advantages compared to the conventional method considering that it was favarable conditions for the teeth, it had the flexibility for the treatment, and it could be the adequate treatment approach for the stomatognathic system. Although this retrospective pilot study had some limitations, due to small samples, the authors would hope that it could serve as a guide for the future reaearches, and the clinical applications.

안면 비대칭의 평가를 위한 기준선에 관한 정모 두부 방사선 계측학적 연구

백선호 한림대학교 1992 국내석사

This study was undertaken to investigate the midline having the least difference between the right and left structures among the lines that had been used in the study of the craniomaxillofacial asymmetry. The sample of this study consisted of twenty six Korean girls(average 18.9 years old) having normal facial appearance and occlusion. On the frontal cephalometric films of the sample, we divided the whole craniomaxillifacial area into four portions, i. e., cranial, upper facial, lower facial, and dental portion. So, we have found the midlines having the least difference in the whole craniomaxillofacial area itself, and in the each divided four portions, furtherly in the other portions from aimed portion. The findings were as follow : 1. In the whole craniomaxiltofacial area, the connecting line between crista galli and anterior nasal spine and the perpendicular bisecting line between right and left foramen rotundums were suitable for the midline. 2. In the cranial portion, established all six lines were suitable for midlines. In the other portions, the perpendicular bisection line between both condylion, the line passing the contact point between right and left mandibular central insisiors among the perpendicular lines between right and left mandibular central incisial tips were suitable midlines for evaluating the asymmetry of cranial portion. 3. In the upper facial portion, the perpendicular bisecting line between right and left zygions was the most suitable midline. In the other portions, the line between the crista galli and the most superior point of the odontoid process, the perpendicular bisecting line between right and left gonions, the perpendicular bisecting line between right and left condylions, and perpendicular bisecting line between right and left foramens rotundum were suitable midlines for evaluating the asymmetry of the upper facial portion. 4. In the dental portion, the perpendicular bisecting lines between right and left buccal cusps of both maxillary first molars and between right and left mandibular first molars were suitable midlines. In the other portions, the perpendicular bisecting line between right and left landmarks crossing the lesser wing of the sphenoid bone and orbit, the perpendicular bisecting line between right and left mental foramens, and the connecting line between crista galli and prosthion were suitable midlines for evaluating the asymmetry of dental portion. 5. In the lower facial portion, the perpendicular bisecting lines between right and left condylions and between right and left gonions were suitable midlines. In the other portions, the line between the crista galli and anterior nasal spine, the perpendicular bisecting line between right and left foramen rotundums, and the perpendicular bisecting lines between right and left buccal cusps of both mandibular first molars and between right and left maxillary first molars were suitable midlines for evaluating the asymmetry of the lower facial portion.

하악골 시상분할 절골술후 하순과 턱에 발생된 감각 이상에 관한 연구

이형상 한림대학교 1992 국내석사

The sagittal split ramus osteotmy has been widely used for the correction of mandibular deformity. Impairment of the inferior alveolar nerve, however, is one of the serious complication inherent in this procedure. This study compared three methods(Table 1) of assessing neurosensory disturbances in patients who underwent bilateral sagittal split ramus osteotomies and genioplasties. Forty cases(22 males, 18 females) ranging in age from 16 to 37 years were analysed in this study. Thirty cases who had bilateral sagittal split ramus osteotomies were stabilized with three tandem-screw fixation and ten cases who had Le Fort I osteotomies, segment osteotomies and genioplasties were stabilized with rigid miniplate osteosynthesis. Neurosensory tests included light touch(LT), two-point discrimination (2-P), and temperature(T) and were performed just prior to surgery, and on the 7th day, 1 month, 6 months and 1 year following surgery. The sensory changes were disappeared completely within six months postoperatively in most sites with mild disturbance,and within one year in severely affected sites. The conclusions were as follows: 1. The incidence of neurosensory disturbances was 48.8%(39/80:right, left inferior alveolar nerves of 40 cases ) in light touch, 26.3%(21/80) in two point discrimination, and 15.0%(12/80) in temperature sensation, but excluding genioplasties, the incidence was 27.3%(12/44), 11.4%(5/44). 4.5%(2/44) respectively. 2. At postoperative six months, a neurosensory disterbance in the LT was seen 17.5%(14/80). and excluding genioplasties the incidence was 6.8%(3/44). 3. All the patients without the evidence of structural damage of the inferior alveolar nerve regained normal neural function within 1 year. 4. Sensory disturbances were clearly related to the degree of intraoperative strain of the inferior alveolar nerve and surgical technique.

한국 성인의 상악 제1대구치 치근단과 상악동 아래벽의 관계에 관한 방사선학적 연구

최빈 한림대학교 2006 국내석사

Maxillary sinus is one of the most large sinus in oral and maxillofacial area. In general, It grow up with facial bone and tooth until 25 years old. At that time, it has a largest volume and sometimes involve maxillary canine, premolar and molar. Cause of their proximity between maxillary sinus and maxillary molar, It is very important. Sometimes It is a source of odontogenic sinusitis and after extraction was done, it can be constitute to make oroantral fistula. many authors reported about their proximity and complication, so they said that it is very important to know about their relationship. we have many method to diagnosis about sinus and tooth. they are periapical view, panoramic view, waters view, computed tomography and magnetic resonance imaging. mostly, we use panoramic view. It has many advantage but it is difficult to distinguish piled image and has a distortion of image. so we investigate distance apecies from maxillary sinus floor and relationship and shape of sinus floor. and also compared panoramic view and tomography image, so we evaluated accuracy of panoramic view as diagnostic method.

가토골수에서 유래된 골모세포를 하악골결손부 이식시 골형성에 미치는 효과

김보균 翰林大學校 2006 국내석사

ABSTRCT- Many people studied defect repair for using biotic materials. Mesenchymal stem cell have the capacity to diffentiate into various cell type. for example osteoblast￡￢condrocytes￡￢myoblasts, and adipocytes. Osteoblasts were aspirated in illiac crest with common method. The method is modification of human bone marrow cell aspiration. Autogenous bone offers directly potentially useful material in maxillofacial bone and implant reconstructive surgery. So autogenous bone is the first choice for bony defect. Autogenous bone was optained in the Madibular bone. Five equal 10mm diameter defect were created in each rabbit Mandible with low speed trepine bur and grafted. 6 rabbits were evaluated at 2,4and 8months. This study failed to show a histomorphometric increase in bone formation with the addition of osteoblast cell to autogenous bone or autogenous bone alone Key word : osteoblasts, Autogenous bone￡￢histomorphometry ³¤

제3대구치 발치시 단계별 생체징후(vital sign)의 변화에 대한 연구

오해수 翰林大學校 2004 국내석사

The 3rd molar extraction of mandible is common in out-patient office of oral and maxillofacial surgery. And it is dynamic minor operation with changes of vital signs, most of patients are already sensitive about their dental treatment. The changes of emotion are reached to the highest level when patients is laid down to be treated on unit chair. It can be induced to undesirable accidents as to this fear. The undesirable complications are nausea, vomiting, hyperventilation, dyspnea, syncope, shock and so on. The severe changes of vital signs may influence their behavior and make serious medical malpractice or suit such as fracture of dental instruments and injury of proximal area. A total of 99 selected normal patients were reviewed. Among this, 70 patients(43 men , 27 women with statistical significance) were included in this study. Each steps(pre-anesthesis, 5 minutes after anesthesia, just after mucogingival incision, just after tooth section, just after suture and gauze biting) were investigated for a change of a vital signs. It is analyzed to 2 categories, "Means" and "Tendency". The "Means" is the amount of vital signs changed in comparison with pre-step during operation. That means is the amount of vital changes by each step operation. Next, "Tendency" is changes of vital signs in comparison with step1 during operation. This is the changing tendency of vital signs with time. That is active effect of fear and pain. Thus this "Means" and "Tendency" will present a sudden changes of vital signs and it can lead to more safe treatment. Thus, the purpose of this study is, through careful operation in each step, to less on patients' complication and increase trust between patient and OMFS. This study is a first article shown with the amount of "Means" and "Tendency" in vital signs, when a third molar of mandible is extracted . This study will be base study of patients with general diseases, because it selected only patients without general diseases.