http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Samal, Monica (검색결과 3 건)
-
-
Human capital for economic development of Kazakhstan : lessons from Korea
Ibrayeva, Samal Tuyakovna Graduate School of International Studies, Korea Un 2014 국내석사
This paper studies the importance of human capital for economic development of a country. Until now, the determinants of economic growth have been analyzed by many researchers around the world. Among the factors we may mention resource enrichment, political freedom, transparency, democracy, openness of economy, geographic location, access to sea and many others. However, probably the most important factor is human capital which determines the quality and effectiveness of how other variables are used by the country. The paper tests if the economic growth of a country is determined by the level of education, healthcare and other factors of human capital. Both quantitative and qualitative analyses are used. For qualitative analysis, such factors as oil reserves endowment, corruption perception index, and HDI and its components are compared with the economic performance of countries. For qualitative analysis, success story of South Korea in developing its human capital is studied, in particular in healthcare and education sectors. Further, Kazakhstan’s human capital is analyzed and recommendations for improvement are given. Overall, the perspectives are bright but several policy amendments should be implemented. Korea’s example shows that the changes should be well planned ahead and should be implemented stage by stage.
-
Samal, Eva University of California, San Diego 2003 해외박사(DDOD)
Gene expression can be regulated by reversible acetylation of chromatin by histone acetyltransferases (HATs) and histone deacetylases (HDACs). The ribosomal DNA (rDNA) array in Saccharomyces cerevisiae is a specialized region where tandem transcription units of identical sequence coexist in both active and inactive forms. A number of distinct chromatin modifiers have been implicated in rDNA chromatin structure and function although how they cooperate or antagonize to modulate rDNA gene expression remains unknown. This work shows that the essential HAT, Esa1p, and the DNA binding repressor activator protein, Rap1p are associated with the rDNA array. Esa1p regulated acetylation of histones affects the binding of Sir2p at the rDNA, and specifically, levels of Sir2p binding parallel histone H4 acetylation levels. Further, deletion of SET1, which encodes the yeast histone H3 Lys4 methyltransferase leads to increased H4 Lys12 acetylation. This work proposes that Set1p mediated methylation antagonizes histone H4 acetylation, thereby restricting Sir2p binding within the genome and supporting efficient gene transcription. Although genome-wide acetylation is suggested to be the essential function of ESA1, the mechanism remains unclear. This study shows that the chromodomain of ESA1 is required for its essential function and that this function is conserved in the chromodomain of the closely related human Tip60 protein. The chromodomain deficient esa1-36Delta73p is targeted to Esa1p targeted loci, the ribosomal protein promoters and the rDNA. In accordance with the role for chromodomains in transcriptional repression and heterochromatin formation, and association of Esa1p with the rDNA, esa1 HAT compromised mutants have rDNA silencing defects. Although, the mechanisms leading to this defect remain unresolved, a genetic approach taken in this study reveals that chromatin modifiers involved in ribosomal protein and rRNA gene expression have prominent rDNA silencing phenotypes. The identification of the rDNA as a new target of Esa1p and an essential role for the chromodomain of ESA1 may help reveal mechanisms by which ribosomal protein gene and rRNA transcription are coordinated. Furthermore, elucidation of a functional significance for the highly dynamic global histone H4Lys12 acetylation and its modulation by the Set1p may help reveal how histone modifications cross-talk to modulate gene expression.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
