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Which way do I go? Strategic representations in rat prefrontal cortex on spatial decision tasks
Powell, Nathaniel James University of Minnesota 2015 해외박사(DDOD)
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The role of the Prefrontal Cortex (PFC) in animal behavior is both complex and subtle. This dissertation concerns the role of rat PFC on spatial decision-making tasks, particularly how it represents strategies or rules necessary to solve these tasks. First I review the current state of knowledge about the role of the rat PFC in regard to behavior and decision-making (Chapter 1). Then I describe the spatial decision-making tasks and electrophysiological recording techniques I used to explore the role of PFC in rats (Chapter 2). Using one of these tasks, I found overlapping populations of PFC neurons that simultaneously encoded multiple relevant task parameters, including some cases in which multiple parameters were encoded by single neurons (Chapter 3). I also describe the spatial firing properties of PFC neurons on these tasks and conclude that although these cells do not seem to directly represent space per se, there are important differences in both single-cell and population representations that corresponded to the animal's location on spatial tasks (Chapter 4). Finally, using a population decoding approach that takes advantage of the spatially coded information in the cells, I identify transitions between different strategic representations in the PFC of animals performing these tasks. In general the transition between states occurred after animals received information that caused them to change their strategy but before the actual change in their behavior. Additionally, these transitions cannot be accounted for solely on the basis of changes to either sensory information or motor output, which proves that these transitions between strategic representational states are cognitive processes (Chapter 5).