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RISS 인기검색어
- 검색키워드
- 저자 : Nam Tae Hoon (검색결과 1 건)
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Nam Tae Hoon 고려대학교 대학원 2014 국내석사
Purpose: To investigate the clinical usefulness of acoustic structure quantification (ASQ) values (mode, average and focal distribution ratio) for hepatic fibrosis in patient with chronic hepatitis and the comparison of it to transient elastography (Fibroscan), biochemical marker (aminotransferase-to-platelet ratio index ;APRI). Material and Methods: We studied consecutively enrolled sixty-two patients with confirmed chronic hepatitis from March 2013 to March 2014. Each patient underwent ASQ evaluation, liver biopsy, and laboratory test. Fifty-four patients among them received transient elastography. Thirty-six healthy adults were enrolled as control group. Control group also underwent ASQ evaluation and laboratory test. Statistical analysis was performed to investigate correlation among each parameter of ASQ, Fibroscan, APRI, and pathologic fibrosis grades. In all statistical analyses, liver biopsy was evaluated as the reference standard according to the METAVIR score. Results: All three ASQ parameters including mode, average value and focal distribution (FD) ratio were significantly correlated with liver fibrosis stage. Among of them, mode value showed the best correlation (p<0.001). On the area under the receiver-operating-characteristic curve (AUROC), mode value of ASQ analysis had significant correlation and good accuracy for diagnosis of any fibrosis (F≥1), significant fibrosis (F≥2), severe liver fibrosis (F≥3), which was 0.8, 0.81, and 0.81, respectively. Those were significantly better than those of average value and FD ratio in F≥1 and F≥2. Fibroscan, mode value and FD ratio in ASQ, showed significant correlation with liver fibrosis stages (p<0.05). There was no statistically significant difference in AUROC between mode value of ASQ and Fibroscan in diagnosis of F≥2 or F≥3. Conclusion: Mode value of ASQ analysis is a promising noninvasive method for the detection of liver fibrosis in the patients with chronic hepatitis.
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