Mass in G for Chorus and Orchestra by Julio Fonseca: Critical Edition and Commentary : JULIO FONSECA, MISA EN SOL PARA CORO Y ORQUESTA: EDICION CRITICA Y COMENTARIO

Gomez Fonseca, Jean A. ProQuest Dissertations & Theses University of Geor 2020 해외박사(DDOD)

Conceptual, preliminary and detailed design of an injection-molded fiber-reinforced plastic/metal hybrid automotive front subframe

Fonseca, João Henrique 서강대학교 대학원 2022 국내박사

The complete design of a recycled-carbon-fiber reinforced-plastic / metal hybrid (PMH) automotive front subframe is realized is realized via finite element (FE) analyses and multiple structural optimization techniques. The structure considers a low-cost recycled carbon fiber (rCF) and PMH technologies. The design is divided into three main steps: the conceptual, preliminary, and detailed design. Conceptual design aims at constructing and analyzing different ideas and approaches before the construction of the actual geometry. This stage is fairly important, since the design of PMH parts is normally complicated; testing the concepts helps predicting future issues in the design, building knowledge regarding the manufacturing process and unique material characteristics, and drawing a proper design approach for the actual product. In Part I, the design and evaluation of PMH front subframes are realized via the design of concept models and FE analyses. Firstly, the design of two PMH front subframe concepts is carried out. The initial design approach consists of creating a C-type and a hollow-type insert and modifying the plastic component according with insert type. Additionally, the design variables considered in the design process are the dimensions of insert, insert thickness, and inclusion of plastic ribs. The PMH front subframes are later evaluated by performance criteria, including weight reduction, stiffness, natural frequency, stress levels under endurance loads, and strength. The results showed that the integration of rCF with injection overmolding of metal inserts was able to promote weight reduction, where the hollow-type and C-type PMH front subframes achieved a weight reduction of 19 % and 16 % in comparison to the reference steel front subframe, respectively. Moreover, the PMH front subframes achieved the desired performance targets set by the evaluation criteria. The preliminary design stage deals with the construction of the initial product geometry and specifications of additional performance requirements. In Part II, the design is realized via combined optimization techniques and their injection molding (IM) suitability verified. Topology optimization (TO) and combined TO and free-size optimization (FSO) techniques are exploited in the design process to find the optimal rib configuration and location of metal inserts. A material exchange technique to account for fiber orientation elementwise is employed and the models analyzed in terms of functionality and producibility. The robust design procedure was shown to be effective in developing sCFRP (short-recycled-carbon fiber reinforced-plastic) and PMH parts while considering IM restrictions and plastic part design guidelines from the early design stages. The PMH model obtained the most outstanding results with the greatest balance between functionality and producibility, with a 36 % weight reduction from the steel baseline model. Although the sCFRP models achieved weight reduction over 50 %, they presented difficulties in simultaneously obtaining the required levels of stiffness, strength and producibility. Detail design refines the preliminary product geometry into a shape that is functionally acceptable and compatible with the IM process. In Part III, the design is carried out via composite size optimization, which considers specific IM design guidelines in order to improve part quality. The complete FE modeling is discussed, where thickness-dependent material properties of the reinforced plastic utilized in this study is automatically updated in the optimization process. In the optimization modeling, user-defined constraints are utilized to improve the efficiency of the algorithm. Moreover, a proper design guideline for the front subframe case is selected based on simulation results. With the procedure, the quality and IM suitability of the PMH subframe was significantly improved, while weight reduction was increased to 38 % with a further simplification of the model. The results of this study contribute to the efficient multimaterial design of PMH components in the auto industry and the advance of a new class of lightweight subframes with improved structural performance, fabricated by fast-capability manufacturing processes and low-cost carbon fibers.

(The) impact of dducational campaign on universal primary education in timor-leste

Fonseca, Celso Da Graduate School of International Studies, Korea Un 2011 국내석사

Cataloging Essential Genes for Natural Transformation and Expanding Genetic Tools for Study of Archaea

Fonseca, Dallas R University of Minnesota ProQuest Dissertations & T 2023 해외박사(DDOD)

Horizontal gene transfer is a near ubiquitous way for organisms to acquire new genetic information. One mechanism of horizontal gene transfer is natural transformation, the uptake/incorporation of DNA from the environment into the genome. In Bacteria, DNA uptake has been well documented in numerous phylogenetically diverse species. Across all of these organisms, four operational steps have to occur. First, the pathway must be induced, entering cells into a state known as competence. Extracellular appendages on the cell then reach out from the cell surface and adsorb DNA. DNA is subsequently translocated through a transporter ComEC and bound by intracellular single-strand binding proteins for integration into the genome.In Archaea, no mechanism of natural transformation has been previously identified and homologs of bacterial competence genes are sparse. Presented here is the identification of the process of natural transformation in two distinct members of the Archaea. Using a variety of genetic techniques, I identify several components that are essential to the natural transformation pathway. This includes Type IV-like pili, putative membrane-bound substrate transporters, proteins predicted to bind DNA, as well as several hypothetical proteins. While this thesis provides the first catalog of genes essential to natural transformation, the exact mechanism that underlies this process is still elusive. The later chapters of this thesis will discuss preliminary approaches to determine the mechanisms of natural transformation mediated DNA uptake. .

Approximate range searching in the absolute error model

Fonseca, Guilherme Dias da University of Maryland, College Park 2007 해외박사(DDOD)

Range searching is a well known problem in computational geometry. We consider this problem in the context of approximation, where an approximation parameter epsilon > 0 is provided. Most prior work on this problem has focused on the relative error model, where each range shape R is bounded, and points within distance epsilon · diam(R) of the range's boundary may or may not be included. We introduce a different approximation model, called the absolute error model, in which points within distance epsilon of the range's boundary may or may not be included, regardless of the diameter of the range. We consider sets of ranges consisting of general convex bodies, axis-aligned rectangles, halfspaces, Euclidean balls, and simplices. We examine a variety of problem formulations, including range searching under general commutative semigroups, idempotent semigroups, groups, range emptiness, and range reporting. We apply our data structures to several related problems, including range sketching, approximate nearest neighbor searching, exact idempotent range searching, approximate range searching in the data stream model, and approximate range searching in the relative model.

Changes in causes of death in HIV/AIDS patients in Brazil in the HAART era

Fonseca Pacheco, Antonio Guilherme University of Pittsburgh 2008 해외박사(DDOD)

The introduction and widespread use of highly active antiretroviral therapy (HAART) in the past decade has changed the profile of HIV/AIDS epidemic. Marked decreases in mortality and morbidity have been reported in low- and high-income settings. Recently, significant relative increases in non-AIDS-associated conditions in HIV-infected individuals have been reported in developed countries. In Brazil, where access to HAART has been universal for all eligible patients since 1996, a steep decrease in mortality among HIV/AIDS patients has also been documented, but the rates have been stable since 1999. So far, no data have been available about the pattern of non-HIV-related mortality in these patients. In these studies, we assessed temporal changes in causes of death among HIV-infected patients in Brazil. In the first paper using Brazilian national mortality data, we demonstrate that, between 1999 and 2004, the odds of having conditions not usually considered to be related to HIV-infection among individuals who had HIV/AIDS listed on their death certificate significantly increased over time. Specific diseases that increased were cardiovascular diseases and diabetes mellitus. In the second paper, we studied temporal trends in cause of death in a cohort of HIV-infected patients in Rio de Janeiro. Results showed an increase of non-AIDS causes of death and a decrease of AIDS causes of death in HIV-infected patients, which appeared to be driven by an aging of the population. This cohort study was facilitated by a linkage algorithm that was developed to recover vital status from patients lost to follow-up. In a third paper that validated the algorithm, sensitivity and specificity were found to be 95% and 100%, respectively. In addition, the use of the algorithm led to a 50% increase in the observed mortality rate. These findings have major public health and programmatic implications for developing countries that are scaling-up access to antiretroviral therapy. In the HAART era, HIV infection has become a manageable disease and is now associated with an increase in chronic illness. Public health measures that are not normally targeted to this population need to be included in their regular care, such as smoking cessation, lipid-lowering drugs, and hypertension control.

Polymer/ceramic wireless MEMS pressure sensors for harsh environments: High temperature and biomedical applications

Fonseca, Michael A Georgia Institute of Technology 2007 해외박사(DDOD)

This dissertation presents an investigation of miniaturized sensors, designed to wirelessly measure pressure in harsh environments such as high temperature and biomedical applications. Current wireless microelectromechanical systems (MEMS) pressure sensors are silicon-based and have limited high temperature operation, require internal power sources, or have limited packaging technology that restricts their use in harsh environments. Sensor designs in this work are based on passive LC resonant circuits to achieve wireless telemetry without the need for active circuitry or internal power sources. A cavity, which is embedded into the substrate, is bound by two pressure-deformable plates that include a parallel-plate capacitor. Deflection of the plates from applied pressure changes the capacitance, thus, the resonance frequency varies and is a function of the applied pressure. The LC resonant circuit and pressure-deformable plates are fabricated into a monolithic housing that servers as the final device package (i.e. intrinsically packaged). This co-integration of device and package offers increased robustness and the ability to operate wirelessly in harsh environments. To intrinsically packaged devices, the fabrication approach relies on techniques developed for MEMS and leverage established lamination-based manufacturing processes, such as ceramic and flexible-circuit-board (flex-circuit) packaging technologies. The sensor concept is further developed by deriving the electromechanical model describing the sensor behavior. The model is initially divided into the electromagnetic model, used to develop the passive wireless telemetry, and the mechanical model, used to develop the pressure dependence of the sensor, which are then combined to estimate the sensor resonance frequency dependence as a function of applied pressure. The derived analytical model allows parametric optimization of sensor designs. The sensor concept is demonstrated in two applications: high temperature and biomedical applications. To demonstrate operation under pressure at temperatures greater than 300°, the current limits for silicon-based MEMS sensors, devices fabricated from low temperature co-fireable ceramics (LTCC) and high temperature co-fireable ceramics (HTCC) using Ag and Pt metallization, respectively, were fabricated and characterized as a function of pressure and temperature. LTCC pressure sensors were operated up to 450° and up to 5 bars of pressure while HTCC devices demonstrated electrical functionality up to 600°. To demonstrate operation in biomedical implantable applications, polymer-based flexible designs were fabricated and characterized. The pressure sensors were fabricated from LCP, polyimide, PTFE substrates using Cu metallization. The sensors were bench-tested in simulated environments for body temperature and fluid, with results exhibiting resonance frequency drift due to the non-hermetic pressure-reference cavities and the polymer moisture absorption. Additionally, the resonance frequency and quality factor of the sensors were significantly reduced when operated in high-permittivity and high-loss dielectric environments. To reduce this performance degradation, a method to passivate the sensors was developed, which used an additional dielectric layer of low permittivity and dielectric loss was introduced. To minimize the sensor drift, this work investigated an alternate design by creating a composite polymer-ceramic sensor. The device retained the flexibility of the external polymeric package while incorporating a hermetic chamber to house the reference pressure and pressure-dependent capacitor. Furthermore, PTFE polymers were selected due to their low moisture absorption. The polymer and polymer-ceramic sensors where characterized for reliability in hydrostatic air, fluid, and pulse pressure (>300 millions cycles simulating more than 7 years of pulse pressure cycles) fluid environments. Testing confirmed the reduction of frequency drift for polymer-ceramic pressure sensors compared to purely polymer-based pressure sensors. Finally, to demonstrate wireless continuous pressure measurements and catheter-based delivery in vivo, LCP-based pressure sensors were delivered into canine models with mock abdominal aortic aneurysms and monitored wirelessly over 30 days. LCP-based pressures sensors were used instead of the composite polymer-ceramic devices because at the time of implant these were still being developed. However, the animal results confirmed both catheter deliverability and wireless telemetry in real biomedical applications.

Essays on Health Economics

Fonseca Martins, Bruno Duarte Boston University ProQuest Dissertations & Theses 2019 해외박사(DDOD)

This dissertation is composed of three essays studying agents' behavior in the health care sector-insurers, patients, and providers-facing different regulatory settings.The first essay studies how vertical integration between pharmacies and insurers affects Medicare Part D premiums. I propose a model of insurer-pharmacy bargaining, which suggests that exposure to a vertically integrated firm should increase other insurers' premiums while lowering the integrated insurer's. I test this using plan-level data from 2006 to 2017, exploiting CVS's acquisition of Target pharmacies. Exposure to this integration increases non-CVS premiums as expected.

Fractionation of whey proteins by complex formation and membrane filtration

Fonseca, Leorges Moraes da The University of Wisconsin - Madison 1999 해외박사(DDOD)

Whey proteins were separated from solutions of whey protein concentrate (WPC). WPC solutions were reacted with equal volumes of pectin, sodium alginate, propylene glycol alginate (PGA), carboxymethylcellulose (CIVIC), and xanthan gum aqueous solutions. Reactions proceeded in the range of pH 2.0 to 6.0. The product was centrifuged at 1200 x g for 30 minutes, and the supernatant was analyzed for protein composition. Protein and nonprotein nitrogen were assayed by the Kjeldahl method. Proteins were quantified by SDS-PAGE electrophoresis and by computer-assisted densitometry. Gel permeation chromatography was used to determine size of soluble complexes formed at low WPC concentration. Precipitation of protein was obtained with sodium alginate, CMC and xanthan gum resulting in total protein precipitation of 90.0% to 95.0% depending on the experimental conditions. Too low WPC concentration resulted in formation of soluble complexes using CMC, low and high viscosity. Amino acid side chains blocking by acetic anhydride revealed electrostatic mechanism of reaction. Important factors affecting reaction were reactant concentration, pH and ionic strength. High ionic strength resulted in less precipitation. Whey protein denaturation was not important affecting the precipitation. Selectivity of protein precipitation occurred with the anionic gums studied using specific conditions. Based on results obtained, a pilot scale and a commercial scale processing were designed to fractionate proteins using xanthan gum solution. Diafiltered WPC (0.7% protein) was reacted with 0.1% xanthan gum aqueous solution at pH 4.5. Alpha-lactalbumin remained in the supernatant and was concentrated to approximately 95% α-lactalbumin (alpha fraction). Precipitate was large fibers, which were held together by smaller fibers held together along a vertical axis, as seen by scanning electronic microscopy. The precipitate was dissolved, separated with isopropyl alcohol, and the liquid phase was diafiltered, ultrafiltered, and dried. This final fraction (beta fraction) contained 90% β-lactoglobulin, besides other minor proteins in the proteic fraction. Functional properties were evaluated.

A Strength-based Framework of College Student Persistence: The Relationships between Campus Racial Climate, Racial Ethnic Identity, Sense of Belonging and Intentions to Persist among Black and Latinx Students attending Predominantly White Institutions

Fonseca-Bolorin, Gloryvee ProQuest Dissertations & Theses University of Mich 2022 해외박사(DDOD)

In alignment with strengths-based role strain adaptation models (Bowman, 2013), my dissertation investigates how social psychological strengths that Black and Latinx students bring to predominantly White higher education environments influence their perceptions and behavior in college. Strength-based models (SBM) highlight the importance of considering an individual’s strengths in counseling interventions and cross-cultural research (Bowman, 2013; 2006). In contrast to widely used deficit frameworks, this study employs a strengths-based approach to understand Black and Latinx college student experiences by focusing on individual and group level strengths that facilitate student adaptation. Utilizing structural equation modeling, I examine how racial ethnic identity along with perceptions of the campus racial climate relate to students’ sense of belonging and intentions to persist. More specifically, I analyze longitudinal survey data from 588 Black and Latinx students in five predominantly white institutions to investigate the direct and indirect influences of campus racial climate (racial ethnic stigma) and three dimensions of racial ethnic identity (centrality, private regard and public regard) on students’ sense of belonging and intentions to persist one academic year later. In addition, this study examines whether dimensions of racial ethnic identity moderate the influence the campus racial climate (racial ethnic stigma) on sense of belonging and intentions to persist. Findings indicate that sense of belonging operated as a mediator and had a consistent and direct relationship to student’s intentions to persist in college. While contextual dimensions of the campus racial climate were important, interpersonal dimensions had a significant relationship to sense of belonging and intentions to persist. More specifically, perceptions of stigma consciousness was negatively associated with belonging and intentions to persist. Surprisingly, only public regard was related to sense of belonging and intentions to persist in college. Also, there were no moderating relationships found between those with different racial ethnic identity beliefs and attitudes and those with different perceptions of the campus racial climate on sense of belonging and intentions to persist. However, when Black and Latinx student were examined separately, perceptions of the classroom inferiorization and stigma consciousness and different beliefs about centrality, private and public regards were considered, the multiplicative effect exacerbated the negative relationship to belonging and intentions to persist. The strength-based model of college student persistence and related study findings have important implications for theory, research and practice. First, the strength-based conceptual model of college student persistence offers an alternative to the deficit lens used to understand Black and Latinx student experiences. Second, the findings have important implications for future research to further clarify the multiples social psychological dimensions of the campus and racial climate ethnic identity in order to understand how lived experiences influence stigmatized students’ persistence in college. Finally, the findings have policy relevance for informing strengths-based strategies that promote persistence among stigmatized student groups and specifically Black and Latinx students by reinforcing the cultural strengths that they bring to their experiences at predominantly White institutions.