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Syntheses and biological evaluation of potentially active sydnone analogues
Dunkley, Christopher S University of the Sciences in Philadelphia 2005 해외박사(DDOD)
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A series of mesoionic compounds (sydnones) were synthesized and evaluated for anticancer and anti-inflammatory activities. The first series of sydnones was designed as potential anti-cancer drugs based on two lead compounds developed by Grynberg et al. Another series of sydnones was designed as potential anti-inflammatory agents based on structural similarities between sydnones and rofecoxib and celecoxib. All compounds were evaluated for anti-cancer activity at the National Cancer Institute (NCI).