로디 도일의 아일랜드성 : 『배리타운 삼부작』과 『패디 클라크 하 하 하』

이유진 韓國外國語大學校 大學院 2006 국내석사

Catholic atomosphere in marie von Ebner-Eschenbach : its useas a literary device : by M. Rosa Doyle

Doyle, M. Rosa Catholic University of America 1936 국내박사

Examination of Longitudinal Associations between Actigraphic Sleep and Ambulatory Blood Pressure in a Community Sample: Three Analysis Comparisons

Doyle, Caroline Yorke ProQuest Dissertations & Theses The University of 2022 해외박사(DDOD)

Objective: Emerging evidence suggests that various dimensions of sleep health are uniquely associated with cardiovascular health, including through sleep effects on acute blood pressure (BP). Prior work, including work from our lab (Doyle et al., 2019) demonstrates that a poor night’s sleep is associated with higher concurrent nighttime BP and elevations the next day. If experienced chronically, this biobehavioral relationship may be a key pathway in the link between sleep and CV health. The current study sought to better establish this pathway to disease by clarifying and extending methodological approaches to conceptualizing BP, determining the reliability of this relationship through replication, and evaluating its chronicity over time.Methods: The current study sought to address these evidence gaps through analysis of data from in 300 men and women aged 21 to 70 years at baseline and 237 at a 2-year follow-up enrolled in The North Texas Heart Study (NTHS), which included ecologically valid assessment of sleep and blood pressure. Actigraphy-assessed sleep was monitored for two consecutive nights, while ambulatory BP was sampled randomly within 45 minute blocks on the first and second day as well as the second night. This protocol was repeated at the second time point, two years later.Results: The previously reported relationship between sleep and daytime BP largely replicated for sleep efficiency, but not for sleep duration, at Time 2 (unadjusted (systolic: (F(1,190)=7.44 , p=.006 , R2=0.033), diastolic: (F(1,190)=5.88, p=0.016 , R2=0.025); partial (systolic: (F(6,80)=4.56 , p=0.010 , R2=0.10), diastolic: (F(6,181)=2.83 , p=0.025 , R2=0.055), fully-adjusted (systolic: (F(8,150)=8.46 , p=0.021 , R2=0.27), diastolic: (F(8,150)=5.13, p=0.049, R2=0.17). The temporal association between lower sleep efficiency one night and higher BP the next day was a particularly stable trend across time points, BP conceptualizations, and models. The results for sleep and nighttime BP at Time 1 (Doyle et al., 2019) largely did not replicate for sleep duration and sleep efficiency at Time 2, except for diastolic BP before full adjustment, indicating small but meaningful difference between sleeping and nighttime BP readings. Longitudinally, Time 1 mean sleep duration and efficiency did not significantly predict change in mean BP from Time 1 to Time 2. This remained true across the three BP conceptualizations.Conclusion: The previously reported cross-sectional associations between sleep efficiency and mean/temporal daytime ABP were largely replicated at follow-up. There was no meaningful difference between “waking” and “daytime” BP values, but there were small but meaningful differences between “sleeping” BP and “nighttime” BP. Sleep did not predict change in BP over a two-year time span. These results support the hypothesis that sleep impacts BP, clarify conceptual use of nocturnal BP terms, and warrant further investigation of this potential pathway to disease.

Characterization of sel-8 and sel-12, two genes that interact with lin-12

Doyle, Timothy George Columbia University 2000 해외박사(DDOD)

LIN-12 and GLP-1 are members of the LIN-12/Notch family of receptors that mediate cell-cell interactions during development. The <italic>sel-8 </italic> and <italic>sel-12</italic> genes were both isolated in screens for suppressors of mutations that constitutively activate LIN-12. I describe the cloning and characterization of <italic>sel-8</italic> and perform functional studies on <italic>sel-12</italic>. Here, I extend the genetic characterization of <italic>sel-8</italic> and clone it, showing that SEL-8 is a novel, highly glutamine-rich, nuclear protein. I also show that <italic>sel-8</italic> is essential for signaling mediated by <italic>lin-12</italic> and <italic>glp-1</italic>. Models are discussed involving the potential role of SEL-8 as a transcriptional coactivator or assembly factor for a transcription complex containing the intracellular domains of LIN-12 or GLP-1. The <italic>sel-12</italic> gene encodes a presenilin, a kind of gene that causes Alzheimer's disease when mutated in humans. Here, I examine the effects of transgenically expressing both <italic>sel-12</italic> and human presenilins with missense mutations that cause Alzheimer's disease. Such mutations cause no obvious gain-of-function phenotypes, but human presenilins show partially reduced ability to functionally substitute for <italic>sel-12 </italic>. I then show that a human presenilin that carries mutations associated with colorectal tumors also show reduced activity in a similar assay. Finally, I show that the mutation of a conserved aspartate residue of <italic>sel-12 </italic> causes the gene to behave like an antimorph when transgenically expressed.

A study of teacher job satisfaction, work-related stress and customer focus in a suburban school district

Doyle, Michael Kelly Wayne State University 2002 해외박사(DDOD)

This study examined job satisfaction, work-related stress, and customer focus in a suburban public school. The purpose of the study was to determine if staff at the elementary, middle, and high school levels in the Trenton Public Schools were satisfied with their jobs, the extent to which they were experiencing work-related stress, and their perceptions of customer focus across the school district. A nonexperimental, descriptive research design was used as the research design in this study. Primary data collection tools included Customer Focus in Education (CFE; Pando, 1992), Quality of Teacher Worklife (QTW; Harringon & Plesma, 1985) and a short demographic survey developed specifically for this study. Both the CFE and QTW instruments had been used extensively in previous research and have documented reliability and validity. The setting for this study was the Trenton Public Schools that included four elementary, one middle and one high school. A total of 178 teachers and staff for the listed buildings were surveyed, with 84 completing and returning for a response rate of 42.4%. Participants were generally satisfied with their jobs and were not experiencing excessive work-related stress. Their perceptions of the customer focus of the schools were significantly above the neutral point, indicating they felt the district fostered a customer focus approach with students and parents. Significant differences in the use of customer focus was found between middle and high school staff in regard to the affective environment as a measure of customer focus. No significant differences were found by building level for job satisfaction or work related stress. Professional characteristics of the participants were not significant predictors of job satisfaction or work-related stress. When teachers and staff were compared on job satisfaction, work-related stress, and customer focus, no statistically significant differences were found. The conclusions indicated that because teachers were generally satisfied and had low levels of work-related stress, they were better able to focus their attention on students. The implications for practice offered strategies that other school districts could use to improve job satisfaction and reduce teacher stress.

A Stochastic theory of advertising decision-making and the theory of the firm

Doyle, Peter Michael University Microfilms International 1984 해외박사

Credit risk measurement and pricing in performance pricing-based debt contracts

Doyle, Jeffrey Todd University of Michigan 2003 해외박사(DDOD)

This dissertation examines how lenders (1) choose a credit risk proxy and (2) link changes in that proxy to the risk premium charged on the loan in performance pricing-based debt contracts. I focus on the choice between accounting ratios and debt ratings as the credit risk proxy. I analyze three attributes of these two measures: timeliness, comprehensiveness, and costliness. I find that performance pricing loans that use accounting ratios are significantly riskier and more likely to be secured than debt rating-based loans. I also find that debt rating-based performance pricing loans are more likely to be given to larger borrowers and borrowers with high absolute levels of accruals. I find mixed results in comparing the actual pricing of performance pricing grids to a theoretical debt pricing model. As expected, the total change in risk premium across the pricing grid is positively associated with the total change in the credit risk proxy across the pricing grid, the average credit risk location of the grid, and the volatility of the borrower. In addition, as predicted, the risk premium is convex in the credit risk proxy, <italic> on average</italic>, within the performance pricing grid. However, many of the individual contracts do not satisfy the convexity prediction and are not well explained by existing debt pricing theory.

Student voice: The influence of complex instruction on fifth grade students' mathematical problem solving performance

Doyle, Jean A Boston College 2003 해외박사(DDOD)

The purpose of this mixed methodological study was to assess the effectiveness of complex instruction, a collaborative group strategy, as an intervention on fifth grade students' mathematical problem solving performances. The design integrated both quantitative (quasi-experimental) and qualitative (case study) approaches that included two comparison groups. Eighty-eight fifth grade pupils were instructed by two, experienced fifth grade mathematics teachers over a 12 week period in the same middle school. Both the control group (N = 48, with one student identified as special needs), and the intervention group (N = 41, with ten students identified as exhibiting special needs in reading, mathematics, or both), received instruction using Connected Math Curriculum. The intervention group was introduced to additional problem solving techniques using Complex Instruction. Complex Instruction (CI), a collaborative instructional strategy, was implemented with the experimental group during three recursive developmental phases: learning to solve problems in collaborative groups; practicing what we learned; and refining our understanding of the problem solving process and CI. Quantitative data included pre and posttests, comprised of objective, short answer and open-ended response released MCAS items. Qualitative data included classroom field observations, focus group interviews, video and audiotapes of student discussions, Individual Student Response Sheets and Group Problem Solving Reports. Descriptive statistics were computed for each quantitative measure. Analysis of variance (ANOVA) and multiple linear regression were used to determine that the intervention group performed significantly higher than the control group on the posttest measures. Qualitative data analysis was implemented to develop a narrative case study. The case study analysis indicated that CI had a positive influence on students' ability to communicate their mathematical understanding of the problem solving tasks. When children are challenged to work on activities collectively and are encouraged to achieve what they are not capable to do individually, learning takes places and development follows promoting higher cognitive processes (Vygotsky, 1978, 1981). Overall as students' awareness and skills in implementing both CI behaviors and the problem solving process evolved, the intervention group developed both a community of respect and a culture for learning which led to improved test scores.

The visibility professionals: The Gay and Lesbian Alliance Against Defamation and the cultural politics of mainstreaming

Doyle, Vincent A University of Massachusetts Amherst 2005 해외박사(DDOD)

Based on archival research, in-depth interviewing, and extensive participant observation carried out over two years in both New York and Los Angeles, this ethnography of the Gay and Lesbian Alliance Against Defamation (GLAAD) critically examines the professionalization of a media advocacy organization and interrogates the value of visibility in contemporary sexual politics. On what and whose terms has the visibility of gays and lesbians been conceptualized and negotiated, and with what consequences for movement politics? How has GLAAD responded to movement tensions between legitimationist and liberationist approaches to social and cultural change? What is the nature of GLAAD's relationships with the media industries and with other movement agents and organizations? What representations does the leading cultural advocate for the gay and lesbian movement help (re)produce and, in the process, which political constituencies does it represent?. I approach GLAAD as a positioned organization in the movement and media fields, in Pierre Bourdieu's sense of the word, in which various agents with stakes in the representation of gays and lesbians compete for various kinds of capital. I describe how, as a result of field positioning objectives, corporate media professionals have come to dominate efforts by the gay and lesbian movement to improve the representation of sexual minorities in mainstream culture. This professionalization has tended to produce normalized representations of gays and lesbians and has fundamentally altered the relationships between the gay and lesbian movement and the media, leading to unprecedented levels of integration. While this integration has contributed greatly to GLAAD's fundraising and institution-building objectives, it has not necessarily led to more influence in the media advocacy system, especially in periods of conflict, and may in fact have made it more difficult for the gay and lesbian movement to advocate effectively on behalf of diverse lesbian, gay, bisexual and transgender constituencies.

Structure-function analysis of Phytophthora parasitica elicitins

Doyle, Elizabeth Ann University of California, Davis 2001 해외박사(DDOD)

Elicitins are elicitor proteins produced by oomycete phytopathogens, primarily <italic>Phytophthora</italic> species. To further characterize the biological properties of elicitins, a structure-function study was undertaken. Systematic mutants, site-directed mutants and non-canonical elicitins were all evaluated for the ability to induce a hypersensitive response (HR) in tobacco. Some of the mutant proteins were evaluated for the ability to induce acquired resistance (AR) and for the ability to bind sterols. Three alanine-scanning mutants, AS-4, AS-8 and BW-3, were 50 to 100-fold impaired in the ability to induce an HR. In addition, mutant AS-1 was unaffected in the ability to induce an HR, yet was unable to induce AR. Several site-directed mutants with significant phenotypes were identified. The mutant L15E was 10 to 100-fold reduced in the ability to induce an HR and was unable to induce AR to <italic>Phytophthora parasitica</italic> var. <italic>nicotianae</italic>. Furthermore, the mutant proteins L41D and L41K were unable to induce an HR in young tobacco plants and were also unable to induce AR. The proteins L41G and L41Q were not impaired, suggesting that a charged residue at position 41 disrupts the parasiticein-tobacco, interaction. The non-canonical elicitins were unaltered relative to the canonical parasiticein in the ability to induce an HR. However, the ELC2 proteins were not able to induce AR. This, and the result from mutant AS-1 would suggest that the ability of elicitins to induce an HR can be separated from the ability to induce acquired resistance. The sterol-binding parameters were determined for parasiticein and seven of the mutant or non-canonical elicitins. Two proteins were unaltered in HR but altered in sterol binding. Y12R was better able to bind sterols, while the elicitin domain of ELC3 was significantly reduced in the ability to bind sterols. Two additional proteins (L15E and L41D) were dramatically reduced in the ability to induce an HR, but only slightly altered in the ability to bind sterols. These results suggest that the ability to induce an HR in tobacco and the ability to bind sterols <italic>in vitro</italic> are not correlated.