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RISS 인기검색어
- 검색키워드
- 저자 : Devadhasan, Jasmine Pramila (검색결과 1 건)
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Smart point-of-care systems for molecular diagnostics based on nanotechnology
Devadhasan, Jasmine Pramila Gachon Univ. 2013 국내박사
Complementary Metal-Oxide-Semiconductor (CMOS) based sensor systems continue to play an important role in various biomedical, chemical, industrial, food safety, national security and defense, and environmental applications. Among several applications, molecular diagnostics have attracted a great deal of consideration in biomedical applications. Objective of this thesis work is to develop CMOS image sensor based molecular diagnostics with a central focus towards the enhancement of point-of-care (POC) approach in whole blood glucose analysis and immunoassay. Development of chip fabrication, synthesis of ammine functionalized silica (AFSiO2) nanoparticles and various thickness of thermally evaporated indium nanoparticle (InNP) substrate preparation are the part of the research to achieve the CMOS image sensor based molecular diagnostics system. The thesis based on the following chapters. Chapter 1 provides the general introduction about CMOS image sensor and their biomedical applications, especially highlighting the CMOS image sensor based molecular diagnostics in glucose monitoring and immunoassay existing in the literature, followed by addressing the virtual need in research and developments for glucose sensor and immune sensor. Chapter 2 describes the CMOS image sensor based glucose monitoring with new approach. To achieve the goal, a series of studies were performed to establish the CMOS image sensor based whole blood glucose monitoring with POC approach. Study 1 is a preliminary investigation for developing novel optical sensor system for measurement of glucose. Experiments in aqueous glucose solution were designed to demonstrate the feasibility of the proposed technique for the glucose monitoring detected by CMOS image sensor. Study 2 demonstrates CMOS image sensor based various concentration of mouse plasma glucose monitoring. Study 3 explains fabrication of PET film chip and synthesis of AFSiO2 nanoparticles for enzyme immobilization were developed for an innovative method of whole blood glucose monitoring using CMOS image sensor as a POC approach. For the analysis, various concentration of mouse whole blood was used to accomplish the assay with real time monitoring. A series of studies were performed to establish the CMOS image sensor based molecular diagnostics in immunosensing which includes in chapter 3, study 1 explains development of InNP substrate by thermal evaporation method and the practical applicability of C-reactive protein (CRP) and troponin I antigen-antibody (Ag-Ab) interaction on various thickness of InNP substrate. Study 2 extends the unraveling the phenomena involved in CMOS image sensor based detection of CRP and troponin I Ag-Ab interaction. Study 3 explains the topographical studies of HIV Ag-Ab interaction and study tried to prove overcomes of non-specific interaction on InNP substrate. Study 4 demonstrates the morphological characterization study of HBV Ag-Ab interaction on InNP substrate and the comparative study of conventional ELISA method. This study proved that the CMOS image sensor is a potential device for immune diagnostics and could be utilized with POC applications. Chapter 4 provides overall concluding remarks and chapter 5 demonstrates the future perspectives about the CMOS image sensor molecular diagnostics the field of glucose monitoring and immunoassay by POC approach. This research will lead to the development of a small, low power, optical sensor for glycemic, cardiac and infectious disease patients, which will be a major breakthrough in the area of molecular diagnostics, upon successful completion of this research and development of the device.
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