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Neuroimaging studies of typical and atypical development
Church-Lang, Jessica Alice Washington University in St. Louis 2008 해외박사(DDOD)
This thesis explores two aims: first, that development can be used as a tool to explore and better understand the mature system, and second, that developmental disorders can enlighten our understanding of typical development, but can also only be understood in the context of typical developmental change. The first aim, explored in part one, describes a set of reading experiments using functional magnetic resonance imaging (fMRI). Chapter 2 characterizes the similarities and differences between adults and children reading familiar single words. The results indicate that there are regions of the brain activated by children for this task that adults do not activate (or activate less). In particular, there are two neighboring brain regions that have been previously proposed to be involved in phonological processing and are more active in children than adults. These results suggest that reliance on phonological processing for familiar words decreases over age. Chapter 3 explores whether the activity in these regions in adults increases when phonological demands are increased. In fact, with increased phonological demands, the two regions show dramatically different activity patterns, and support the idea that one region is involved in phonological processing, while the other's role in reading is less clear. The second aim is explored in part two, in which two techniques, fMRI and functional connectivity MRI (fcMRI) are used to explore differences in top-down control in adolescents with and without Tourette Syndrome (TS). Chapter 4 uses fcMRI to uncover differences in functional correlations among putative control regions in adolescents with TS. These differences are revealed by looking both at connections that change over typical development, and by looking at connections of difference between unaffected and TS adolescents. Chapter 5 uses a similar approach to explore the TS group in the context of an fMRI design targeted to extract top-down control signals in the brain. The results of both chapters indicate the adolescents with TS show general functional immaturity in top-down control signaling, with putative adaptive control regions showing the greatest differences between groups. Overall these studies emphasize the importance of a developmental context in understanding brain function.