http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : CHOU HUNGCHUN (검색결과 1 건)
-
CHOU HUNGCHUN 경희대학교 대학원 2018 국내석사
The objective of this study was to observe the effects of water extracts of Rehmannia glutinosa on the glutamate-induced inward current that heterologously express human NMDA receptor. The N-methyl-D-aspartate (NMDA) receptor is one of three types of ionotropic glutamate receptors, the others being the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. In the present study, we investigated the regulatory effects of the water extracts of Rehmannia glutinosa on the glutamate-induced inward current that heterologously express human NMDA receptor. The current was measured using the two-electrode voltage clamp technique. In this study, we found the water extracts of Rehmannia glutinosa inhibited glutamate induced current in a reversible and concentration-dependent manner. The IC50 was about 51.2 μg/ml. The water extracts of Rehmannia glutinosa action on glutamate induced current was attenuated by increasing glutamate concentration, and was membrane holding potential-dependent. These results show a possibility that the water extracts of Rehmannia glutinosa interacts with NMDA receptor, which was heterologously expressed and that the water extracts of Rehmannia glutinosa on glutamate induced current of NMDA receptor could be one of contributions of Rehmannia glutinosa-mediated neuroprotections.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
