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RISS 인기검색어
- 검색키워드
- 저자 : Beane Freeman, Laura Elizabeth (검색결과 1 건)
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Arsenic exposure, artificial tanning and melanoma in Iowa
Beane Freeman, Laura Elizabeth The University of Iowa 2003 해외박사(DDOD)
Exposure to ultraviolet radiation (UVR) has long been implicated in the development of cutaneous melanoma. Artificial tanning devices, which emit UVR, may mimic exposure to the sun and increase melanoma risk. Self-tanning cream use is becoming increasingly common, which may also impact melanoma risk. We examined artificial UVR and self-tanning cream use in relation to melanoma. Studies of basal and squamous cell carcinoma have reported an increased risk with arsenic exposure. We explored a potential association between arsenic and cutaneous melanoma. In this case-control study, the associations between cutaneous melanoma and environmental arsenic exposure, artificial tanning, and outdoor occupational exposure were evaluated in Iowans ages 40 and older. Participants included 368 melanoma cases and 373 colorectal cancer controls diagnosed in 1999 and 2000, frequency-matched on year of diagnosis, gender and 5-year age category. Participants completed a mailed survey and submitted toenail clipping samples for analysis of arsenic content. We found an increased risk of melanoma in participants with elevated toenail arsenic concentrations (Odds Ratio [OR] = 2.1; 95% Confidence Interval [CI] = 1.4–3.4) and effect modification by prior skin cancer diagnosis (p-interaction = 0.0298). For those with prior skin cancer, the OR was 7.0 (95% CI = 2.2 = 22.8), while for those without prior skin cancer the OR was 1.7 (95% CI = 1.0–2.9). The use of a shallow well for residential drinking water, which has been linked with higher arsenic levels, was associated with increased melanoma risk (OR = 1.6; 95% CI = 1.0–2.6). We found a suggestion of effect modification with use of sunlamps and skin color. For those with medium or dark skin color, the OR was 2.0 (95% CI = 1.0–8.0), while the OR for those with fair skin was 1.1 (95% CI = 0.6–1.8). We found no association between use of self-tanning creams and melanoma risk. When we examined total number hours spent outdoors on the job, we found a significant increased risk of melanoma for those participants who spent more time outdoors (OR = 2.2; 95% CI = 1.2–5.1). A reliability study conducted as part of the overall project showed that the survey instrument was generally reliable (most ≥0.6) and there was little or no evidence of non-differential exposure misclassification.
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