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최언 전북대학교 의학전문대학원 2011 국내박사
Osteoporosis is characterized by compromised bone strength predisposing a person to an increased risk of fracture. Long-term administration of currently prevalent medicaments may lead to an increased risk of severe side effect like cancer. Accumulating evidence suggest Salvia Miltiorrhiza have anti-osteoporotic effect. To seek out natural products that can manage osteoporosis and concurrently have less side effects, we observed anti-osteoporotic property of Salvia Miltiorrhiza in ovariectomized rats by assessment of serum biochemical parameters, bone turnover markers, inflammatory cytokines and oxidative stress parameters, measurement of bone mineral density (by dual-energy X-ray absorptiometry), analysis of trabecular bone structural parameters (by microcomputerized tomography scanning) and histological analysis of bone and liver. Result of experiment: ovariectomy significantly reduced bone mineral density and trabecular bone architecture, increased bone turnover, inflammatory cytokines and oxidative stress parameters. ovariectomy also aggravated mononuclear cellular infiltration in liver portal area induced by aging. while SM treatment significantly ameliorated bone mineral density and trabecular bone mass decrease and increase in inflammatory cytokines and oxidative stress parameters by the 30 mg/kg body weight/day dosage. ovariectomy significantly increased bone turnover and hence induced trabecular bone loss. Salvia Miltiorrhiza treatment significantly attenuated decrease in bone mineral density and trabecular architecture deterioration induced by ovariectomy. The preventive effect of SM was presumably by its anti-oxidative stress and anti-inflammatory activity partly via modulating bone turn over rate. In current study, Salvia Miltiorrhiza is suggested as a promising osteoporosis therapeutic natural product.