RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      선택해제

      오늘 본 자료

      • 오늘 본 자료가 없습니다.
      더보기
      • 단삼의 난소제거 흰쥐에 대한 항골다공증 효과

        최언 전북대학교 의학전문대학원 2011 국내박사

        RANK : 247615

        Osteoporosis is characterized by compromised bone strength predisposing a person to an increased risk of fracture. Long-term administration of currently prevalent medicaments may lead to an increased risk of severe side effect like cancer. Accumulating evidence suggest Salvia Miltiorrhiza have anti-osteoporotic effect. To seek out natural products that can manage osteoporosis and concurrently have less side effects, we observed anti-osteoporotic property of Salvia Miltiorrhiza in ovariectomized rats by assessment of serum biochemical parameters, bone turnover markers, inflammatory cytokines and oxidative stress parameters, measurement of bone mineral density (by dual-energy X-ray absorptiometry), analysis of trabecular bone structural parameters (by microcomputerized tomography scanning) and histological analysis of bone and liver. Result of experiment: ovariectomy significantly reduced bone mineral density and trabecular bone architecture, increased bone turnover, inflammatory cytokines and oxidative stress parameters. ovariectomy also aggravated mononuclear cellular infiltration in liver portal area induced by aging. while SM treatment significantly ameliorated bone mineral density and trabecular bone mass decrease and increase in inflammatory cytokines and oxidative stress parameters by the 30 mg/kg body weight/day dosage. ovariectomy significantly increased bone turnover and hence induced trabecular bone loss. Salvia Miltiorrhiza treatment significantly attenuated decrease in bone mineral density and trabecular architecture deterioration induced by ovariectomy. The preventive effect of SM was presumably by its anti-oxidative stress and anti-inflammatory activity partly via modulating bone turn over rate. In current study, Salvia Miltiorrhiza is suggested as a promising osteoporosis therapeutic natural product.

      연관 검색어 추천

      이 검색어로 많이 본 자료

      활용도 높은 자료

      해외이동버튼