공공기관의 고성과 인적자원관리 시스템이 조직몰입에 미치는 영향

정원춘 공주대학교 2019 국내석사

The purpose of this study is to present a strategic alternative at the administrative level of public agency operations by identifying the high-altitude and the impact of human resource management systems on the intakes of organizations. To achieve the purpose of this study, the high-performance human resources management system was divided into three areas: ability development (education training), motivation (compensation, internal mobility), and participation opportunities, and the relationship between variables was established through the literature review of the organizational immersion. For verification purposes, the survey was conducted on employees of City Hall in Boryeong, Chungcheongnam-do, and the collected data were verified using reliability and factor analysis, correlation analysis and simple and multi-return analysis. The results of this study's hypothesis verification show that the ability development, motivation, and participation opportunities of high-performance and human resource management systems have a statistically significant positive effect on organizational intakes. In addition, it was found that the lower the rank, the more effective the high-level and human resource management systems were to form an organizational inflow. Therefore, the various education and training programs provided by public institutions, standardized education training for job performance, and education and training for promotion opportunities mean that the better the level of organizational immersion of the members of the public institution, the more important the education and training of the public institutions are. Appropriate compensation systems in personnel management will increase interest and attachment to the organization. Therefore, adequate compensation through objective and fair evaluation is an effective factor for members of public institutions to be immersed in the organization. Transparency in promotion opportunities and career management in public institutions is a factor that can further solidify organizational immersion by providing vision and future to organizational members. If a member of a public institution has adequate authority over his or her duties and a high level of awareness of the level of participation in an organization's decision-making, the level of organizational immersion increases as a result of an increased sense of belonging to the organization and self-esteem.

定志丸의 기억 및 인지기능 향상에 대한 효능 연구

정원춘 대구한의대학교 대학원 2011 국내석사

This study was aimed to investigate the memory enhancing effect of Jeongjihwan against scopolamine-induced amnesia in C57BL/6 mice. To determine the effect of Jeongjihwan on the memory and cognitive function, we have injected scopolamine (1 mg/kg, i.p.) into C57BL/6 mice 30 min before beginning of behavior tests. We have conducted Y-maze, Morris water-maze, passive avoidance and fear conditioning tests to compare learning and memory functions. Scopolamine-induced behavior changes of memory impairment were significantly restored by oral administration of Jeongjihwan (100 or 200 mg/kg/day). To elucidate the molecular mechanism underlying the memory enhancing effect of Jeongjihwan, we have examined the antioxidant defense system and neurotrophic factors. Jeongjihwan treatment attenuated intracellular accumulation of reactive oxygen species and up-regulated mRNA and protein expression of antioxidant enzymes as assessed by RT-PCR and western blot analysis, respectively. Jeongjihwan also increased protein levels of brain-derived neurotrophic factor (BDNF) compared with those in the scopolamine-treated group. Furthermore, as an upstream regulator, the activation of cAMP response element-binding protein (CREB) via phosphorylation was assessed by Western blot analysis. Jeongjihwan elevated the phosphorylation of CREB (p-CREB), which seemed to be mediated partly by extracellular signal-regulated kinase1/2 (ERK1/2) and protein kinase B/Akt. These findings suggest that Jeongjihwan may have preventive and therapeutic potential in the management of amnesia. 본 연구의 목적은 스코폴라민(scopolamine)이 유도하는 건망증에 대한 定志丸의 기억력 향상 효과를 C57BL/6 마우스를 사용하여 실험적으로 증명하는 것이다. 기억 및 인지기능 행동실험에서 定志丸의 효능을 검토하기 위하여 행동 실험 시작 30분전에 스포콜라민을 1 mg/kg의 용량으로 복강 주사 하였으며, 학습 및 기억력 비교를 위해 Y-미로(Y-maze), 모리스 물-미로(Morris water-maze), 수동회피(passive avoidance)와 공포조건화(fear conditioning) 실험 등의 행동 실험을 수행 하였다. 스코폴라민에 의해 유도되는 기억력 손상에 의한 행동 변화는 100 mg/kg 및 200 mg/kg 定志丸의 경구 투여에 의해 유효성 있게 회복되었으며, 이러한 定志丸의 기억력 강화 효과에 대한 분자기전 규명을 위해 항산화 방어계 및 신경영양인자 지표들을 확인하는 일련의 실험을 수행하였다. 定志丸의 경구 투여함으로써 세포내 활성산소(reactive oxygens species, ROS) 축적과 세포내 항산화 물질인 글루타치온(glutathione) 양 감소, 지질과산화로 인한 4-hydroxynonenal (4-HNE) 생성 등의 산화적 손상이 억제되었다. 한편 이러한 효과는 항산화 효소인 γ-glutamylcysteine ligase (GCL)와 superoxide dismutase(SOD)의 mRNA 및 단백질 발현 증가와 관련됨을 Western blot과 RT-PCR을 통하여 밝혔다. 더 나아가 신경영양인자중 하나인 brain-derived neurotrophic factor (BDNF)의 단백질 발현 또한 定志丸에 의해 증가되었으며, 이는 상위조절인자인 extracellular signal-regulated kinase 1/2 (ERK1/2) 와 protein kinase B/Akt (PKB)의 인산화에 의한 cAMP response element-binding protein (CREB)의 활성화를 통하여 매개되는 것으로 추정되었다. 이상의 결과는 定志丸이 항산화 기능을 가짐으로 산화적 손상을 억제하고 신경영양인자의 활성화를 유도하여 신경세포 보호함으로써 건망증을 포함한 기억력 손상 관련 질환의 예방 및 치료제 활용될 수 있음을 시사한다.

만성 골반통에 대한 한의학 임상연구 동향분석

정원춘 대구한의대학교 2019 국내박사

The aim of this paper is to investigate and analyse clinical evidence of Korean medicine treatment for chronic pelvic pain. 10 electronic databases were searched up to June 2018. Clinical studies (e.g. case studies, case controlled trials, randomized controlled trials or cohort studies) that reported the effectiveness of korean medicine treatment for chronic pelvic pain were included and analysed. A total of 23 clinical studies (Case studies; n=12, Randomized controlled trials; n=11) were included in the review. Among them, acupuncture was utilized in 11 papers (91.7%) and frequently used acupuncture points were SP6 (三陰交), LI4 (合谷), PC6 (內關). For herbal medicine of 10 studies (83.3%), Banchong-san (蟠葱散) was the most frequently used in chronic pelvic pain patients diagnosed as endometriosis, adenomyosis and ovarian cyst. For moxibustion of 8 studies (66.7%), CV3 (中極), CV4 (關元), CV6 (氣海), CV12 (中脘) and ST25 (天樞) were most utilized moxibustion point. 11 Randomized controlled trials of chronic pelvic pain were included in this studies. Of these, five types of intervention such as acupuncture (45.5%), electro-acupuncture+auricular acupuncture+moxibustion (18.2%), electro-acupuncture (18.2%), herbal medicine (9.1%) and catgut embedding therapy (9.1%) were utilized in Korean medicine treatment groups. For control groups, sham acupuncture was used in 4 studies (36.4%), Western medicine used for 3 papers (27.3%) and sham acupuncture+moxibustion was utilized in 2 studies (18.2%). This review suggests that Korean medicine intervention were effective in treating chronic pelvic pain. However, it is difficult to recommend Korean medicine treatment as an evidence-based treatment due to small number of studies. In the future, well-designed clinical studies with larger number of patients are should be conducted. 본 연구의 목적은 만성 골반통에 한의학치료를 적용한 임상연구를 조사 및 분석하여 만성 골반통에 대한 한의학 치료 가이드라인을 제시하기 위함이다. 2018년 8월에 국내외 10개의 데이터베이스에서 만성 골반통에 한의학 치료를 적용한 임상연구 23편 (증례연구 12편, 무작위대조군연구 11편)의 논문을 분석대상으로 선정하였다. 만성 골반통 관련 12편의 증례연구 중 침이 11편 (91.7%)의 논문에서 사용되었으며, 다빈도 혈자리는 삼음교, 합곡, 내관으로 나타났다. 한약처방이 10편 (83.3%)의 논문에서 사용되었으며, 가장 많이 사용된 반총산은 자궁내막증, 자궁선근증, 난소낭종을 동반한 만성 골반통 환자에게 처방하였다. 뜸이 8편 (66.7%)의 논문에서 사용되었으며, 다빈도 뜸자리는 중극, 관원, 기해, 중완, 천추로 나타났다. 11편의 만성 골반통 관련 무작위대조군연구 중 한의학 치료군에 사용된 중재법은 침 (45.5%), 전침+이침+뜸 (18.2%), 전침 (18.2%), 한약 (9.1%), 매선 (9.1%)으로 나타났다. 대조군에 사용된 중재법을 보면, 가짜침이 가장 많은 4편 (36.4%), 양약이 3편 (27.3%), 가짜침+뜸이 2편 (18.2%)의 논문에서 사용되었다 본 연구는 한의학 치료법이 만성 골반통 환자 치료에 효과가 있음을 보여주었다. 하지만, 한의학 치료법을 만성 골반통의 표준치료로 제시하게에는 논문 수가 부족하였다. 향후 많은 환자를 대상으로 한 질 높은 임상연구가 수행되어, 만성 골반통의 한의학 치료 가이드라인이 제시되길 바란다.