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24 patients with advanced head and neck cancer were treated with etoposide, doxorubicin and cisplatin(EAP) between July, 1987 and April, 1990. 1) Among 16 evaluable patient, overall response rate was 68% (complete response 25% partial response rate 43% ). 2) Median response duration was 7 month ; 4 month and 17.5 month for partial responders and complete responders respectively. 3) Median survival was 10 month for all patients and 15 month and 5 month for responders and nonrespoders respectively; there was statistically significant, difference(p<0.01). 4) There was no significant statistical difference in the response rate according to patient characteristics. 5) Frequent non-hematologic toxicity were nausea and vomiting. A1opecia, stomatitis, fever and diarrhea were observed infrequently, leukopenia and thrombocytopenia were observed in 8%, hepatotoxicity and nephrotoxicity were rare. In conclusion, EAP combination chemotherapy in patients with advanced head neck cancer gas relatively effective and well tolerable.