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RISS 인기검색어
- 검색키워드
- 저자 : 메하리 엔달 (검색결과 1 건)
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Suaeda asparagoides (Miq.) has been used as Korean folk herbal medicine for the treatment of functional gastrointestinal disorders. However, reports on its pharmacological activity on gastrointestinal motility are scares. The present study aimed at investigating the effects of Suaeda asparagoides aqueous fraction of the extract (SAWF), on antral motility in vitro. Muscle strips from rat gastric antrum were set up in organ baths in circular orientation. SAWF concentration dependently (0.1-100 ?g/ml) inhibited the spontaneous contraction of antral circular muscle strips. The effects of SAWF (100 ?g/ml) were not affected by tetrodotoxin (1 ?M), atropine (1 ?M), L-NAME (100?M), ryanodine (10 ?M), 2-APB (10 ?M) and phentolamine (10?M). However, ODQ (10 ?M) significantly (P<0.05) attenuated the extract induced inhibition. SAWF evoked inhibition was also significantly (P<0.01) attenuated by CPA (10 ?M) and thapsigargin (10 ?M). Further more, ?-adrenergic receptor antagonist, propranolol (10?M) abolished (P<0.001) SAWF induced inhibition. These results suggest that SAWF may exert its activity on gastrointestinal smooth muscle via adrenergic path ways that involve ?-adrenergic receptors and SR Ca2+ pump (Sarcoplasmic Endoplasmic Reticulum Ca2+ ATPase (SERCA)) involving mechanisms.
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