Abstract Anti-nociceptive activity of Corylopsis gotoana Park, Zi Won Dept. of Oriental Pharmacy College of Pharmacy Graduate School of Woosuk University (Directed by Prof. Jeon, Hoon, Ph.D.) Corylopsis gotoana has been widely used as a traditio...
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https://www.riss.kr/link?id=T14050812
완주: 우석대학교 일반대학원, 2016
학위논문(석사) -- 우석대학교 일반대학원 일반대학원 , 한약학과 , 2016. 2
2016
한국어
전북특별자치도
vi,29pp.: 삽도; 26cm.
우석대학교 논문은 저작권에 의해 보호받습니다.
지도교수:전훈
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다운로드다국어 초록 (Multilingual Abstract)
Abstract Anti-nociceptive activity of Corylopsis gotoana Park, Zi Won Dept. of Oriental Pharmacy College of Pharmacy Graduate School of Woosuk University (Directed by Prof. Jeon, Hoon, Ph.D.) Corylopsis gotoana has been widely used as a traditio...
Abstract
Anti-nociceptive activity of Corylopsis gotoana
Park, Zi Won
Dept. of Oriental Pharmacy
College of Pharmacy
Graduate School of Woosuk University
(Directed by Prof. Jeon, Hoon, Ph.D.)
Corylopsis gotoana has been widely used as a traditional medicine for the treatment of lots of disease including cold, edema and vomiting. However pharmacological and phytochemical studies on the C. gotoana are extremely limited. Here in this study, the author investigated the anti-nociceptive effects of the methanolic extract of Corylopsis gotoana (MCG) using various pain models. In the present study, MCG exhibited strong and dose-dependent anti-nociceptive activities on various experimental pain models including thermal nociception and chemical nociception, compared to positive control such as tramadol and indomethacin. In addition, the result from combination test using naloxone, analgesic activity of MCG was slightly reduced, indicating that MCG acts as a partial opioid receptor agonist. These results demonstrated that MCG has potent analgesic potential and thus it may be possibly used as a valuable anti-nociceptive agent.
목차 (Table of Contents)