Case report of amniotic membrane derived-stem cells treatment for feline chronic obstructive pulmonary disease

다국어 초록 (Multilingual Abstract)

A cat who is a 15-year-old and spayed female visited an animal clinic with severe coughing symptoms. Since the cat’s coughing symptoms had worsened from the age of 10 and X-rays showed a bronchial pattern in the lungs, it was diagnosed as Chronic Obstructive Pulmonary Disease (COPD). She received three injections of stem cells isolated from the amniotic membrane on days 0, 7, and 23. Although there was no improvement in the clinical findings on the x-ray, the number of coughing was significantly reduced. In addition, even after long-term follow-up post treatment for a month, she was stable with almost no coughing.

참고문헌 (Reference)

1 이효종, "제대혈 유래 중간엽줄기세포에서 HLA의 발현과 Mixed Lymphocyte Reaction" 한국임상수의학회 28 (28): 399-402, 2011

2 Quimby JM, "Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats : results of three sequential pilot studies" 4 : 48-, 2013

3 Mathers CD, "Projections of global mortality and burden of disease from 2002 to 2030" 3 : e442-, 2006

4 Liu X, "Preclinical studies of mesenchymal stem cell(MSC)administration in chronic obstructive pulmonary disease(COPD) : a systematic review and metaanalysis" 11 : e0157099-, 2016

5 Chang YP, "Mortality and vertebral fracture risk associated with long-term oral steroid use in patients with chronic obstructive pulmonary disease : a systemic review and meta-analysis" 16 : 1479973119838280-, 2019

6 Guan XJ, "Mesenchymal stem cells protect cigarette smoke-damaged lung and pulmonary function partly via VEGF-VEGF receptors" 114 : 323-335, 2013

7 Zhen G, "Mesenchymal stem cell transplantation increases expression of vascular endothelial growth factor in papain-induced emphysematous lungs and inhibits apoptosis of lung cells" 12 : 605-614, 2010

8 De Coppi P, "Isolation of amniotic stem cell lines with potential for therapy" 25 : 100-106, 2007

9 Trzil JE, "Intravenous adipose-derived mesenchymal stem cell therapy for the treatment of feline asthma : a pilot study" 18 : 981-990, 2016

10 Patel SA, "Immunological properties of mesenchymal stem cells and clinical implications" 56 : 1-8, 2008

11 McEvoy CE, "Corticosteroids in chronic obstructive pulmonary disease. Clinical benefits and risks" 21 : 739-752, 2000

12 Vidane AS, "Cat amniotic membrane multipotent cells are nontumorigenic and are safe for use in cell transplantation" 7 : 71-78, 2014

13 노슬아, "Case reports of amniotic membrane derived-cell treatment for feline chronic renal failure" 사단법인 한국동물생명공학회 36 (36): 116-120, 2021

14 Nemeth K, "Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweedinduced asthma" 107 : 5652-5657, 2010

15 Huh JW, "Bone marrow cells repair cigarette smokeinduced emphysema in rats" 301 : L255-L266, 2011

16 Kavanagh H, "Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells" 66 : 523-531, 2011

17 McEvoy CE, "Adverse effects of corticosteroid therapy for COPD. A critical review" 111 : 732-743, 1997

18 Park HK, "Adipose-derived stromal cells inhibit allergic airway inflammation in mice" 19 : 1811-1818, 2010