家兎繼代牛疫毒의 變異에 關한 硏究 = A Study on the Variation of Rabbit-Passaged Strain Ⅲ of the Nakamura Lapinized Rinderpest Virus

다국어 초록 (Multilingual Abstract)

Nakamura and his associates reported that the pathogenesis of rabbit-passaged Strain Ⅲ of the Nakamura lapinized rinderpest virus (hereinafter referred to as the "Strain Ⅲ") is fixed in rabbit and cattle.
However, we found that a serial passage of this "Strain Ⅲ" and its p thogenesis become more virulent and almost all the rabbits that were infected with this "Strain Ⅲ" died in 1947. If we assume that the increase in its virulence is due to the variation of its pathogenesis by the more serial passage of this "Strain Ⅲ", it is an importanr problem in the preventaion of epidemics of Rinderpest virus in cattle.
An attempt was made in our laboratory to investigate the variation of the "Strain Ⅲ" and the following conclusions were made.
1) The increase of death rate in rabbit is not due to a mixinfection of other pathogenic organisms nor symbiosis with other organisms but it has been proved that it is due to the variation of its pathogenesis.
2) The pathologic change and the necrotic process of the lymph follicular cells in infected rabbits seem to be different in this study from the one reported previously by others. Particularly the cause of sever hemorrhagic change in the mucosa of gastrointestinal tract is not clear and more study will be needed to clearly its pathogenesis.
3) The minial infectious dose of this "Strain Ⅲ" in rabbits is higher in this study than in previous studies.
4) The neutralizaing potency of the convalescent serum of infected rabbit is more lower in this study than in previous works.
5) The following results were obtained by an inoculation of this "Strain Ⅲ" to Korean calves.
a) The minimal infectious dose for calves is much higher in this study than in previous studies.
b) There were died case and recovered case in claves inoculate with this "Strain Ⅲ". This is similar in this study to the previous works.
c) Some difference was noted in appearance of critical symptoms in this study.
d) The entire course and incubation period of infected calves were shorted considerably in this study than in previous works.
6) The results of simultaneous inoculation with this "Strain Ⅲ" plus antirinder pest hyperimmune serum to Korean calves also indicated that the pathogenesis of this "Strain Ⅲ" becaome more virulent than in previous studies.
7) The successive passage of theis "Strain Ⅲ" through Korean calves showed the following results.
a) In calves the pathogenesis become more virulent but at no time it acquired the virulence of Rinderpest virus.
b) The death rate of infected calves is higher in this study than in previous studies.
c) When the blood of infected calves were inoculated into rabbits, fever and necrosis of the lymph follicular cells were seen and this characteristics of this "Strain Ⅲ" was maintained unitl the last passage of this study.
d) Minimal infectious dose of blood from infected calves was markedly low ans this is due to the difficulty in reproducation of this "Strain Ⅲ" in calves.
8) The simultaneous inoculation with this "Strain Ⅲ" plus antirinderpest hype rimmune serum which is used in Korea is safe for cattles but it is dangerous for calves. For this reason increased dose of immune serum must be used for calves.

목차 (Table of Contents)

• Ⅰ. 豫備的事項
• 1. 緖 論
• 2. 牛疫豫防法의 變遷 및 本硏究에 對한 基礎的 考察
• 3. 硏究의 目標 및 그에 있어서의 基礎的 觀察
• Ⅱ. 實驗成積
• 1. 細菌學的 檢索
• 1) 檢索方法
• 2) 實驗結果
• 3) 檢索成積에 對한 考察
• 2. 病理解部學的 觀察
• 1) 病理解部學的 所見
• 2) 感染의 經過와 壤死淋巴濾胞細胞의 發現 및 消長
• 3) 病理解部學的 觀察에 對한 考察
• 3. 毒價測定試驗 (M. I. D. 試驗)
• 1) 家兎에 對한 毒價測定試驗
• 2) 犢에 對한 毒價測定試驗
• 3) 實驗成積에 對한 考察
• 4. 中和試驗
• 1) 血淸稀釋法에 依한 中和試驗
• 2) 病毒稀釋法에 依한 中和試驗
• 3) 實驗成積에 對한 考察
• 5. 韓國牛種犢에 對한 家兎系毒의 接種試驗 및 犢體通過復歸試驗
• 1) 實驗成積
• ① 犢에 對한 家兎系毒의 最少感染量試驗
• ② 犢에 對한 家兎系毒의 單味接種試驗
• ③ 犢에 對한 家兎系毒의 共同接種試驗
• ③ 家兎系毒의 接種通過 復歸試驗
• 2) 各實驗成積에 對한 考察
• 6. 韓國牛種成牛에 對한 家兎系毒의 接種試驗
• 1) 實驗材料 및 實驗方法
• 2) 實驗成積
• 3) 實驗成積에 對한 考察
• Ⅲ. 結論
• 參考文獻