스펙트럼 영역 빛간섭단층촬영 결과에 영향을 주는 다양한 인자 분석 = Analysis of Factors Associated with Variability in Measures Obtained by Spectral Domain Optical Coherence Tomography

다국어 초록 (Multilingual Abstract)

Purpose: To identify factors associated with variability in measures obtained by spectral domain optical coherence tomography (SD-OCT). Methods: One hundred ninety-six subjects (370 eyes) with no ophthalmic evidence of retinopathy and with corrected visual acuities better than 0.6 were included. Macular thickness and retinal nerve fiber layer (RNFL) thickness were measured using SD-OCT and were analyzed according to sex, laterality, age, spherical equivalent and signal strength. Results: The central subfield thickness was significantly lower in the female subjects (r = -0.260, p = 0.000). As age increased, average inner and outer macular thickness increased significantly (r = 0.153, p = 0.010; r = 0.193, p = 0.001). Spherical equivalent correlated negatively with central subfield thickness (r = -0.352, p = 0.000) but correlated positively with average inner macular thickness, average outer macular thickness, overall average thickness, overall macular volume, and average RNFL thickness (r = 0.181, p = 0.002; r = 0.287, p = 0.000; r = 0.346, p = 0.000; r = 0.341, p = 0.000; and r = 0.261, p = 0.000, respectively). Signal strength correlated negatively with average inner macular thickness (r = -0.136, p = 0.023). Conclusions: SD-OCT shows that retinal thickness is related to age, sex, spherical equivalent and signal strength. Analysis of retinal thickness by SD-OCT should be interpreted in the context of these findings. J Korean Ophthalmol Soc 2012;53(5):639-646

참고문헌 (Reference)

1 김승훈, "정시안에서 스펙트럼영역 빛간섭단층촬영기를 이용한 연령과 성별에 따른 황반 두께의 변화" 대한안과학회 52 (52): 299-307, 2011

2 문성운, "시간영역과 스펙트럼영역 빛간섭단층촬영기의 황반두께 측정치 및 반복성의 비교" 대한안과학회 50 (50): 1050-1059, 2009

3 김부기, "시간영역 빛간섭단층촬영기와 스펙트럼영역 빛간섭단층촬영기로 측정한 망막신경섬유층 두께 비교" 대한안과학회 50 (50): 1539-1547, 2009

4 강명수, "스펙트럼영역 빛간섭단층촬영기로 측정한한국인 정상안의 황반부 용적" 대한안과학회 51 (51): 1077-1083, 2010

5 이영록, "녹내장 진단에서 스펙트럼 영역 빛간섭단층촬영기로 측정한 황반과 망막신경섬유층 두께의 유용성" 대한안과학회 51 (51): 1250-1257, 2010

6 Lim MC, "Use of optical coherence tomography to assess variations in macular retinal thickness in myopia" 46 : 974-978, 2005

7 Evans JR, "Systemic risk factors for idiopathic macular holes: a case-control study" 12 (12): 256-259, 1998

8 "Risk factors for idiopathic macular holes. The Eye Disease Case-Control Study Group" 118 : 754-761, 1994

9 Massin P, "Retinal thickness in healthy and diabetic subjects measured using optical coherence tomography mapping software" 12 : 102-108, 2002

10 Panda-Jonas S, "Retinal photoreceptor density decreases with age" 102 : 1853-1859, 1995

11 Wong AC, "Relationship of gender, body mass index, and axial length with central retinal thickness using optical coherence tomography" 19 : 292-297, 2005

12 Lam DS, "Regional variations in the relationship between macular thickness measurements and myopia" 48 : 376-382, 2007

13 Landau D, "Quantitative in vivo retinal thickness measurements in healthy subjects" 104 : 639-642, 1997

14 Zou H, "Quantitative in vivo retinal thickness measurement in Chinese healthy subjects with retinal thickness analyzer" 47 : 341-347, 2006

15 Schuman JS, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography" 113 : 586-596, 1995

16 Chan CM, "Posterior pole retinal thickness measurements by the retinal thickness analyzer in healthy Chinese subjects" 26 : 176-181, 2006

17 Varma R, "Optical tomography-measured retinal nerve fiber layer thickness in normal latinos" 44 : 3369-3373, 2003

18 Yanoff M, "Ocular Pathology, A Text and Atlas" Haper & Row 513-514, 1982

19 Duan XR, "Normal macular thickness measurements using optical coherence tomography in healthy eyes of adult Chinese persons: the Handan Eye Study" 117 : 1585-1594, 2010

20 Chan A, "Normal macular thickness measurements in healthy eyes using Stratus optical coherence tomography" 124 : 193-198, 2006

21 Asrani S, "Noninvasive mapping of the normal retinal thickness at the posterior pole" 106 : 269-273, 1999

22 Wakitani Y, "Macular thickness measurements in healthy subjects with different axial lengths using optical coherence tomography" 23 : 177-182, 2003

23 Eriksson U, "Macular thickness decreases with age in normal eyes: a study on the macular thickness map protocol in the Stratus OCT" 93 : 1448-1452, 2009

24 Nussenblatt RB, "Macular thickening and visual acuity. Measurement in patients with cystoid macular edema" 94 : 1134-1139, 1987

25 Lee SC, "Macular Thickness Variations with Sex, Age, and Axial Length in Healthy Subjects: A Spectral Domain-Optical Coherence Tomography Study" ASSOC RESEARCH VISION OPHTHALMOLOGY INC 51 (51): 3913-3918, 2010

26 Samarawickrama C, "Influence of OCT signal strength on macular, optic nerve head, and retinal nerve fiber layer parameters" 51 : 4471-4475, 2010

27 Wu Z, "Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography" 114 : 1505-1512, 2007

28 Budenz DL, "Determinants of normal retinal nerve fiber layer thickness measured by Stratus OCT" 114 : 1046-1052, 2007

29 Apple DJ, "Clinicopathologic Correlation of Ocular Disease : A Text and Stereoscopic Atlas" Mosby 39-44, 1978