SD 랫트를 이용하여 四君子湯의 아급성 독성에 관한 연구 = Subacute Toxicity Study on Sagunju-tang(Sijunzi-tang) in SD Rats

다국어 초록 (Multilingual Abstract)

Sagunja-tang(Sijunzi-tang) has been traditionally prescribed as a restorative. The present study was undertaken to determine the possible toxic effects of Sagunja-tang on SD rats. In this study, we investigated the subacute toxicity of water-extracted Sagunja-tang(Sijunzi-tang) on SD rats. Twenty rats were orally adiministered Sagunja-tang for 28 days at a dose of 0 ㎎/㎏(control group) or 1500㎎/㎏(treated group), respectively. All of subjects was survived. No significant difference in abnormal clinical signs, related to hematological values, serum biochemical values, water and feed intake, coagulation time, autopsy analysis, organ weight, tissue microscopically, funduscopy, urine intake and urinalysis, was detected. Compared with the control group, we could not find any subacute toxic alteration in treated group (l500㎎/㎏) for 28 days. This result suggests that Sagunja-tang(Sijunzi-tang), a herbal medicine prescription, is a safe prescription to body.

목차 (Table of Contents)

• Ⅰ. 서론
• Ⅱ. 재료 및 방법
• Ⅲ. 결과
• Ⅳ. 고찰 및 결론
• Ⅴ. 참고문헌