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https://www.riss.kr/link?id=A3367102
1985
-
500
SCOPUS,KCI등재,ESCI
학술저널
107-113(7쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Serum gastrin and group 1 pepsinogen levels were checked by radioimmunoassay in 97 subjects. They consisted of 28 healthy control subjects, 10 patients with gastric ulcer, 14 with doudenal ulcer, 15 with chronic gastritis and 30 with gastric cancer. P...
Serum gastrin and group 1 pepsinogen levels were checked by radioimmunoassay in 97 subjects. They consisted of 28 healthy control subjects, 10 patients with gastric ulcer, 14 with doudenal ulcer, 15 with chronic gastritis and 30 with gastric cancer. Postoperative serum gastrin and pepsinogen 1 levels were evaluated in 8 patients among the gastric cancers. The following results were obtained; 1) The mean levels of fasting serum gastrin and PG 1 of patients with gastric ulcer did not show any differences as compared with normal control groups. 2) The patients with doudenal ulcer showed significantly higher mean levels of fasting serum PG 1 as compared with normal control(p<0.001). 3) The patients with chronic gastritis had not significant relationship between the mean levels of fasting serum gastrin as compared with normal control, but mean serum PG 1 values revealed some elevated state (p<0.001). 4) Patients with gastric cancer had significantly lower mean levels of fasting serum gastrin as compared with normal control(p<0.025). 5) Gastric resection was performed in 8 patients among gastric cancer, and serum gastrin and PG 1 levels were compared preoperatively and postoperatively. Gastrin levels were significantly reduced after gastrectomy. It was concluded that serum gastrin and PG 1 may be valuable in diagnosis of peptic ulcer, especially doudenal ulcer and may be useful as subclinical marker for gastric cancer.