눈안삽입콘택트렌즈 삽입술 후 각막내피세포의 변화 = Corneal Endothelial Changes After ICL (Implantable Collamer Lens) Insertion

다국어 초록 (Multilingual Abstract)

Purpose: To evaluate the stability of corneal endothelial cells after ICL (implantable contact lens) implantation. Methods: Retrospective review of 50 eyes were subjected to implantation of ICL by one surgeon from December 2003 to April 2008. During the follow-up period, the number of eyes with regular follow-up decreased and remained at 18 eyes at the time of a three-year follow-up. Patients were examined preoperatively and at one, three, and six months and one, two, and three years postoperatively. The main outcome measures were the change in corneal endothelial cell density (CD), coefficient of variation (CV), and hexagonality (HA). This analysis was done in all eyes and especially in the 18 eyes with regular follow-up for three years and 11 eyes with changes in CV and HA corresponding to the normal endothelial wound healing process for three years. Results: Corneal endothelial CD, CV, and HA were not significantly changed compared with their preoperative values throughout the three-year follow-up period for all eyes. In the early postoperative period, there was a slight decrease in CD, but it increased after the second year of follow-up (range: -3.12%~+2.84%); there was a slight increase in CV, but it decreased after the six-month follow-up (-6.63%~+5.56%); and there was a slight decrease in HA, but it increased after the three-month follow-up (range: -0.88%~10.64%). Similarly, there were no significant changes in corneal endothelial cell density in the 18 eyes with regular follow-up or the 11 eyes with changes in CV and HA corresponding to normal endothelial wound healing process for three years. Conclusions: The results show stability of corneal endothelial cells after ICL implantation.

참고문헌 (Reference)

1 전연숙, "중등도 이상의 근시환자에서 ICL (Implantable Contact Lens) 수술의 임상 결과" 대한안과학회 45 (45): 480-489, 2004

2 한상엽, "고도근시 환자에서 안내후방콘택트렌즈삽입술의 중장기간 임상결과" 대한안과학회 48 (48): 465-472, 2007

3 García-Feijoó J, "Ultrasound Biomicroscopy examination of posterior chamber phakic intraocular lens position" 110 : 163-172, 2003

4 Huang PT, "The morphology and function of healing cat corneal endothelium" 30 : 1794-1801, 1989

5 Sibug ME, "Specular microscopiy studies on the corneal endothelium after cessation of contact lens wear" 10 : 395-401, 1991

6 Jiménez-Alfaro I, "Safety of posterior chamber phakic intraocular lenses for the correction of high myopia" 108 : 90-99, 2001

7 Bernard EM, "Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and intraocular drugs and solutions" 27 : 1-16, 2008

8 Pesando PM, "Posterior chamber phakic intraocular lens (ICL) for hyperopia: Ten-year follow up" 33 : 1579-1584, 2007

9 Budo C, "Multicenter study of the Artisan phakic intraocular lens" 26 : 1163-1171, 2000

10 Kim KS, "Morphometric analysis of the corneal endothelial cells in normal Korean" 33 : 320-325, 1992

11 Lackner B, "Long term results of implantation of phakic posterior chamber intraocular lenses" 30 : 2269-2276, 2004

12 Bourne WM, "Long term observation of morphologic and functional features of cat corneal endothelium after wounding" 35 : 891-899, 1994

13 Dejaco-Ruhswurm I, "Long term endothelial changes in phakic eyes with posterior chamber intraocular lenses" 28 : 1589-1593, 2002

14 Ling TL, "Long term changes in corneal endothelial morphology following wounding in the cat" 29 : 1407-1412, 1998

15 Odenthal MT, "Long term changes in corneal endothelial morphology after discontinuation of low gas permeable contact lens wear" 24 : 32-38, 2005

16 Ichijima H, "In vivo confocal microscopic studies of endothelial wound healing in rabbit cornea" 12 : 369-378, 1993

17 Lee SY, "Implantable contact lens to correct high myopia (clinical study with 24 months followup)" 41 : 1515-1522, 2000

18 Bechmann M, "Imaging of posterior chamber phakic intraocular lens by optical coherence tomography" 28 : 360-363, 2002

19 Sanders DR, "ICL in Treatment of Myopia Study Group. United States Food and Drug administration Clinical Trial of the Implantable Collamer Lens (ICL) for moderate to high myopia" 111 : 1683-1692, 2004

20 Edelhauser HF, "ICL in Treatment of Myopia Study Group. Corneal endothelial assessment after ICL implantation" 30 : 576-583, 2004

21 Chang SW, "Effects of contact lenses on corneal endothelium-a morphological and functional study" 215 : 197-203, 2001

22 Bourne WM, "Central corneal endothelial cell changes over a ten-year period" 38 : 779-782, 1997