Heme Oxygenase-1: Its Therapeutic Roles in Inflammatory Diseases

다국어 초록 (Multilingual Abstract)

Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes
the first and rate-limiting step in the oxidative degradation
of free heme into ferrous iron, carbon monoxide (CO),
and biliverdin (BV), the latter being subsequently converted
into bilirubin (BR). HO-1, once expressed during inflammation,
forms high concentrations of its enzymatic by-products
that can influence various biological events, and this expression
is proven to be associated with the resolution of
inflammation. The degradation of heme by HO-1 itself, the
signaling actions of CO, the antioxidant properties of
BV/BR, and the sequestration of ferrous iron by ferritin all
concertedly contribute to the anti-inflammatory effects of
HO-1. This review focuses on the anti-inflammatory mechanisms
of HO-1 actions and its roles in inflammatory diseases.

다국어 초록 (Multilingual Abstract)

Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes
the first and rate-limiting step in the oxidative degradation
of free heme into ferrous iron, carbon monoxide (CO),
and biliverdin (BV), the latter being subsequently converted
into bilirubin (BR). HO-1, once expressed during inflammation,
forms high concentrations of its enzymatic by-products
that can influence various biological events, and this expression
is proven to be associated with the resolution of
inflammation. The degradation of heme by HO-1 itself, the
signaling actions of CO, the antioxidant properties of
BV/BR, and the sequestration of ferrous iron by ferritin all
concertedly contribute to the anti-inflammatory effects of
HO-1. This review focuses on the anti-inflammatory mechanisms
of HO-1 actions and its roles in inflammatory diseases.

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