1 Baker RG, "inflammation,and metabolic disease" 13 : 11-22, 2011
2 Lin J, "Transcriptional co-activator PGC-1 alpha drives theformation of slow-twitch muscle fibres" 418 : 797-801, 2002
3 15Houtkooper RH, "The secretlife of NAD+ : an old metabolite controlling new metabolicsignaling pathways" 31 : 194-223, 2010
4 Bai P, "The role of PARP-1 and PARP-2 enzymes inmetabolic regulation and disease" 16 : 290-295, 2012
5 Gross DN, "The role of FoxOin the regulation of metabolism" 27 : 2320-2336, 2008
6 Tornatore L, "The nuclear factor kappa B signaling pathway : integratingmetabolism with inflammation" 22 : 557-566, 2012
7 Krishnakumar R, "The PARP side of the nucleus:molecular actions, physiological outcomes, and clinicaltargets" 39 : 8-24, 2010
8 Brunet A, "Stress-dependent regulation of FOXO transcriptionfactors by the SIRT1 deacetylase" 303 : 2011-2015, 2004
9 Feige JN, "Specific SIRT1 activation mimics low energy levelsand protects against diet-induced metabolic disorders byenhancing fat oxidation" 8 : 347-358, 2008
10 Houtkooper RH, "Sirtuins as regulators ofmetabolism and healthspan" 13 : 225-238, 2012
1 Baker RG, "inflammation,and metabolic disease" 13 : 11-22, 2011
2 Lin J, "Transcriptional co-activator PGC-1 alpha drives theformation of slow-twitch muscle fibres" 418 : 797-801, 2002
3 15Houtkooper RH, "The secretlife of NAD+ : an old metabolite controlling new metabolicsignaling pathways" 31 : 194-223, 2010
4 Bai P, "The role of PARP-1 and PARP-2 enzymes inmetabolic regulation and disease" 16 : 290-295, 2012
5 Gross DN, "The role of FoxOin the regulation of metabolism" 27 : 2320-2336, 2008
6 Tornatore L, "The nuclear factor kappa B signaling pathway : integratingmetabolism with inflammation" 22 : 557-566, 2012
7 Krishnakumar R, "The PARP side of the nucleus:molecular actions, physiological outcomes, and clinicaltargets" 39 : 8-24, 2010
8 Brunet A, "Stress-dependent regulation of FOXO transcriptionfactors by the SIRT1 deacetylase" 303 : 2011-2015, 2004
9 Feige JN, "Specific SIRT1 activation mimics low energy levelsand protects against diet-induced metabolic disorders byenhancing fat oxidation" 8 : 347-358, 2008
10 Houtkooper RH, "Sirtuins as regulators ofmetabolism and healthspan" 13 : 225-238, 2012
11 Rajamohan SB, "SIRT1 promotes cell survival understress by deacetylation-dependent deactivation ofpoly(ADP-ribose)polymerase 1" 29 : 4116-4129, 2009
12 Herranz D, "SIRT1 : recent lessons from mousemodels" 10 : 819-823, 2010
13 Pacher P, "Role of poly(ADP-ribose)polymerase 1(PARP-1)in cardiovascular diseases : the therapeuticpotential of PARP inhibitors" 25 : 235-260, 2007
14 Lagouge M, "Resveratrol improves mitochondrialfunction and protects against metabolic disease byactivating SIRT1 and PGC-1alpha" 1147 : 275-282, 2006
15 Liu D, "Preventing NAD(+)depletionprotects neurons against excitotoxicity : bioenergetic effectsof mild mitochondrial uncoupling and caloric restriction" 1147 : 275-282, 2008
16 Masutani M, "Poly(ADP-ribosyl)ation in relation to cancer andautoimmune disease" 62 : 769-783, 2005
17 Szanto M, "Poly(ADP-ribose)polymerase-2 depletion reducesdoxorubicin-induced damage through SIRT1 induction" 92 : 430-438, 2011
18 Pillai JB, "Poly(ADP-ribose)polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reducedSir2alpha deacetylase activity" 280 : 43121-43130, 2005
19 Shevalye H, "Poly(ADP-ribose)polymerase(PARP)inhibition counteracts multiple manifestations of kidneydisease in long-term streptozotocin-diabetic rat model" 79 : 1007-1014, 2010
20 Jagtap P, "Poly(ADP-ribose)polymerase and thetherapeutic effects of its inhibitors" 4 : 421-440, 2005
21 Pang J, "Poly(ADP-ribose)polymerase 1 is involved in glucose toxicitythrough SIRT1 modulation in HepG2 hepatocytes" 112 : 299-306, 2011
22 Qin WD, "Poly(ADP-ribose)polymerase 1 inhibition protects againstlow shear stress induced inflammation" 1833 : 59-68, 2013
23 Pillai JB, "Poly(ADP-ribose) polymerase-1-deficient mice areprotected from angiotensin II-induced cardiac hypertrophy" 291 : H1545-H1553, 2006
24 Bai P, "PARP-2 regulates SIRT1 expression and whole-bodyenergy expenditure" 13 : 450-460, 2011
25 Bai P, "PARP-1 inhibition increases mitochondrial metabolismthrough SIRT1 activation" 13 : 461-468, 2011
26 Rodgers JT, "Nutrient control of glucose homeostasisthrough a complex of PGC-1alpha and SIRT1" 434 : 113-118, 2005
27 Tanno M, "Nucleocytoplasmic shuttling of the NAD+-dependenthistone deacetylase SIRT1" 282 : 6823-6832, 2007
28 Kominsky DJ, "Metabolic shifts inimmunity and inflammation" 184 : 4062-4068, 2010
29 Nicolas L, "Loss of poly(ADP-ribose)polymerase-2 leads torapid development of spontaneous T-cell lymphomas inp53-deficient mice" 29 : 2877-2883, 2010
30 Fong PC, "Inhibition of poly(ADP-ribose)polymerase in tumorsfrom BRCA mutation carriers" 361 : 123-134, 2009
31 Mota RA, "Inhibition of poly(ADP-ribose)polymerase attenuates the severity of acute pancreatitis andassociated lung injury" 85 : 1250-1262, 2005
32 Mangerich A, "Inflammatory and age-relatedpathologies in mice with ectopic expression of humanPARP-1" 131 : 389-404, 2010
33 Muiras ML, "Increasedpoly(ADP-ribose) polymerase activity in lymphoblastoid celllines from centenarians" 76 : 346-354, 1998
34 Hanahan D, "Hallmarks of cancer : the nextgeneration" 144 : 646-674, 2011
35 Liu TF, "Fueling the flame : bioenergy couples metabolism andinflammation" 92 : 499-507, 2012
36 Houtkooper RH, "Exploring the therapeutic spacearound NAD+" 199 (199): 205-209, 2012
37 Tong WM, "DNA strandbreak-sensing molecule poly(ADP-Ribose) polymerasecooperates with p53 in telomere function, chromosomestability, and tumor suppression" 21 : 4046-4054, 2001
38 Canto C, "Crosstalk betweenpoly(ADP-ribose)polymerase and sirtuin enzymes" 34 : 1168-1201, 2013
39 Kolthur-Seetharam U, "Control of AIF-mediated cell death by thefunctional interplay of SIRT1 and PARP-1 in response to DNAdamage" 5 : 873-877, 2006
40 Ford AL, "Climbing STAIRs towards clinical trials witha novel PARP-1 inhibitor for the treatment of ischemicstroke" 1410 : 120-121, 2011
41 Shapiro H, "Ariel A. Macrophages,meta-inflammation, and immuno-metabolism" 11 : 2509-2529, 2011
42 Massudi H, "Age-associated changes in oxidative stress andNAD+ metabolism in human tissue" 7 : e42357-, 2012
43 Underhill C, "A review of PARPinhibitors : from bench to bedside" 22 : 268-279, 2011
44 Luo X, "A one and a two expanding roles forpoly(ADP-ribose)polymerases in metabolism" 13 : 353-355, 2011