Synthesis of Two step Indole Derivatives in a Continuous Flow System = Synthesis of Two step Indole Derivatives in a Continuous Flow System

다국어 초록 (Multilingual Abstract)

Indole derivatives are used as antibiotics in pharmaceuticals and have various physiological and biological characteristics such as antipyretic, anti-fungal and anti-inflammatory. In this study, the reaction proceeds in two steps. First of all, the first reaction is C3-formylation of indole in the microreactor. As a secondary reaction, the synthesis of Tri(indolyl)methanes(TIM) is carried out by acid catalyst reaction using Indole and Indole-3-carboxyaldehyde synthesized by C3-formylation of Indole. In the case of the first reaction, the microreactor optimized various parameters to obtain 76% yield in 10 minutes. However, the secondary reaction TIM synthesis is difficult to apply to the microreactor because the product is solid. In this study, the problem of solid formation in the Microreactor can be solved by generating product and disperse phase using mineral oil as a carrier phase during synthesis.