유한요소법에 의한 골강도와 micro-CT 지표 및 골밀도간의 상관관계 = Analysis on correlation between bone strength by FEA, micro-CT parameters and bone mineral density

다국어 초록 (Multilingual Abstract)

Purpose : Bone mineral density (BMD) and bone microarchitecture are important determinants for bone strength. Recently micro-CT have provided possibilities for measuring a variety of structural indices to characterize bone microarchitecture. The objective of this study was to compare the BMD and micro-CT parameters with Young's modulus calculated by finite element analysis(FEA) for the evaluation of bone strength.
Materials and Methods : Bone specimens were obtained from the 18 female rabbits aged 16 weeks. Of those, 36 samples (right and left femur) were selected for 3D micro-CT analysis (ANT^(TM), SKYSCAN, Belgium) and BMD by PIXImus 2 (GE Lunar Co. USA). Five microstructural parameters of micro-CT, such as trabecular thickness (Tb.Th), bone specific surface (BS/BV), percent bone volume (BV/TV), structure model index (SMI) and degree of anisotropy (DOA) were studied. Young's modulus was obtained by software program (ANSYS 9.0, ANSYS Inc, Canonsburg, PA) based on micro-CT three dimensional images.
Results : Young's modulus assessed by FEA correlated significantly with Tb.Th, BV/TV, BS/BV and SMI respectively. Young's modulus showed higher correlation with these microstructural parameters of micro-CT than BMD. Microstructural parameters except DOA showed significant correlations within the examined group.
Conclusion : The microarchitectural parameters of micro-CT and BMD represented some informations in the evaluation of bone strength assessed by FEA. (Korean J Oral Maxillofac Radiol 2007; 37: 53-9)