광범위 회전근 개 파열에서 인대보강술의 역할

국문 초록 (Abstract)

회전근 개 파열은 어깨 관절의 심한 통증과 기능 저하, 근력 약화를 유발하는 흔한 원인 중의 하나이다. 이 질환에 대한 이해와 수술적인 치료의 발전에도 불구하고, 광범위 회전근 개 파열의 수술적 치유 결과는 파열 크기가 작은 경우에 비하여 저조한 것으로 알려져 있다. 이러한 높은 실패율은 환자 자신의 내재적 치유 능력에 영향을 미치는 생물학적인 요인뿐 아니라 기계적인 요인에 기인한다. 최근 조직 공학적으로는 회전근 개 봉합의 치유를 돕기 위하여 지지체(scaffold)나 성장 호르몬, 간엽 줄기세포(mesenchymal stem cell) 등에 관한 연구가 활발이 이루어지고 있다. 지지체는 기계적인 강도와 생물학적인 치유를 증진시킬 목적으로 관심이 높아지고 있다. 저자들은 이 종설에서 회전근 개 복원술에 사용되는 지지체 중에서 가장 널리 사용되고 있는 세포 외 기질 지지체의 최근 연구 경향 및 임상적인 응용에 대하여 살펴보고자 한다.

다국어 초록 (Multilingual Abstract)

Rotator cuff tears are a common cause of debilitating pain, reduced shoulder function, and weakness. Despite improvements in the understanding of the disease process and advances in surgical treatment, recent studies have reported that healing of massive rotator cuff tears is not as predictable as that of smaller rotator cuff tears. These high failure rates are a result of both mechanical and biologic factors that may affect the patients’ intrinsic capacity to heal. Most research studies have concentrated on tissue engineering as a means for improvement of healing in rotator cuff repair, including the use of scaffolds, growth factors, and mesenchymal stem cells. There has been much interest in the development of various scaffolds that provide adequate strength as well as stimulate and enhance healing potential. The purpose of this paper is to review the current basic science and clinical application of extracellular matrix scaffolds, which are currently the most widely used scaffolds for repair of rotator cuff tears.

목차 (Table of Contents)

• 서론
• 회전근 개 파열 시 인대 보강술의 적용
• 생역학적 특성(Biomechanical properties)
• 생화학적 특성(Biochemical properties)
• 동물 실험 결과
• 임상 연구 결과
• 수술 수기
• 요약
• 결론
• 참고문헌

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