Wegener 육아종증의 진단과 치료에 대한 임상적 경험 = Clinical Experiences of Diagnosis and Treatment for Wegener’s Granulomatosis

다국어 초록 (Multilingual Abstract)

Because most patients with Wegener’s granulomatosis (WG) visit otolaryngologists complaining
of head and neck symptoms, otolaryngologists may play an important role in early diagnosis. In this study, we investigated
clinical features, laboratory findings and treatment outcomes of 33 patients with WG, and propose a new algorithm for the diagnosis
of WG. Subjects and Method：Thirty-three patients with WG who visited the clinic between January 1980 and December
2007 were included. The medical records of 13 male and 20 female patients were retrospectively reviewed. The mean
follow-up duration was 68 months. Results：Most WG patients had ENT symptoms such as nasal obstruction, rhinorrhea, otorrhea,
hearing loss, dyspnea and hoarseness. The mean duration from ENT examination to diagnosis was 6.7 months (3 days-
102 months) and tissue biopsy was performed on an average of 2.1 times to confirm the diagnosis. While 16 patients could be
diagnosed by the first biopsy, the others were required to repeat the biopsy. ANCA was positive in 17 patients (50%). Twentysix
patients (78.7%) had multiple organ involvements such as lung, kidney, joint and skin. Twenty-eight patients received a combination
of prednisolone and cyclophosphamide with the remission rate of 87%. Conclusion：Based on this study, we propose a
better algorithm for the diagnosis of WG to avoid unnecessary delay in the diagnosis and treatment of WG. (Korean J
Otorhinolaryngol-Head Neck Surg 2008;51:1109-18)

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