흰쥐를 이용한 플루르비프로펜 겔의 약물동력학적 특성평가 = Pharmacokinetic Evaluation of Flurbiprofen Gel Using Rats

다국어 초록 (Multilingual Abstract)

The pharmacokinetic characteristics of an 1% flurbiprofen gel were evaluated using rats in reference to IV bolus and oral administration of the drug using rats. Following the transdermal application of the gel at the dose of 2mg/kg as flurbiprofen, the Cmax and Tmax of the drug were 2.14mcg/ml and 2 hr, respectively, whereas those after the oral administration of the drug as a suspension were 9.90mcg/ml and 0.25 hr, respectively. These results indicate that, by the transdermal administration of flubiprofen as the gel, the absorption of the drug was much slowed down and the lower Cmax compared to the oral administration may reduce the systemic side effects of the drug. The relative bioavailability of the flurbiprofen gel in reference to the oral dose was 48.5%. Tissue levels of flurbiprofen following the application of 50mg of the 1% flurbiprofen gel onto ventral skin of rats showed that the maximum drug concentrations in the skin (8.52mcg/g) and the muscle (2.06mcg/g) occurred at 2 hrs postdose. The drug concentration in the both tissues remained relatively constant over the next 6 hrs following the peak concentration.