두부 외상을 동반한 골절 환자의 혈청에서 Receptor Activator of Nuclear Factor-κB Ligand와 Osteoprotegerin의 변화 = Alterations in Serum Levels of Receptor Activator of Nuclear Factor-κB Ligand and Osteoprotegerin in Patients with Head Injury and Fracture

국문 초록 (Abstract)

목적: RANKL과 OPG는 골의 재형성에 있어 파골기전의 중요한 조절 인자이며, 골절의 치유 과정에 관여한다. 그러나 두부 외상과 골절이 있는 환자에서 이들에 대한 연구는 부족하다. 이에 두부 외상을 동반한 골절 환자군과 골절 환자군의 혈청에서 이들의 변화를 분석하여 비교하였다. 대상 및 방법: 두부 외상과 골절이 있는 18명의 남자 환자와 골절이 있는 20명의 남자 환자, 대조군으로 건강한 20명의 남자를 선정하였다. 두부외상-골절군과 골절군에서 수상 후 수 시간 내, 수상 후 4, 8, 12주에 혈액을 채취하여 RANKL과 OPG의 변화를 분석하였다. 결과: 두부외상-골절군은 외상 후 8, 12주에 골절군에 비하여 RANKL의 발현이 낮았으며 두부외상-골절군에서 골절군에 비하여 외상 후 4, 8,12주에 OPG의 발현이 증가되었다. 두부외상-골절군에서 외상 후 수 시간 내, 4, 8, 12주에 대조군보다 RANKL/OPG의 비율이 낮았으며, 두부외상-골절군에서 골절군에 비해 외상 후 8주와 12주에 RANKL/OPG 비율이 낮았다. 결론: 두부 외상과 골절이 있는 환자에서 RANKL, OPG, RANKL/OPG의 비율의 변화를 보았고, 두부 외상과 골절이 있는 환자에서 이들의 변화가 골절 환자에서 보다 오랫동안 지속되었다.

다국어 초록 (Multilingual Abstract)

Purpose: Receptor activator of nuclear factor-κ B ligand (RANKL), osteoprotegerin (OPG) have been shown to be important regulators of osteoclastogenesis during bone remodeling, and their expressions were examined during fracture healing in a mouse model of tibial fracture. However, studies linking RANKL and OPG in patients with head injury and fracture are lacking. We evaluated the changes in serum levels of RANKL and OPG in patients with head injury and fracture (head injury group) and in patients with fracture (fracture group) and compared these with levels found in healthy control subjects. Materials and Methods: 18 male patients of head injury and fracture and 20 male patients of fracture alone were enrolled. 20 healthy men were recruited to serve as controls. Within the first few hours of admission to hospital, at 4, 8 and 12 weeks after injury 20 ml of blood were obtained from 18 patients with head injury and fracture and 20 patients with fracture only. Results: RANKL levels were significantly lower in the head injury group than in the fracture group at 8 and 12 weeks after injury. OPG levels were significantly higher in the head injury group than in the fracture group at 4, 8 and 12 weeks after injury. RANKL/OPG ratios were significantly lower in the head injury group than in the controls immediately after and 4, 8 and 12 weeks after injury, and were significantly lower in the head injury group than in the fracture group at 8 and 12 weeks after injury. Conclusion: We have shown changes in the profiles of RANKL, OPG and RANKL to OPG ratio. The altered RANKL, OPG and RANKL/OPG ratio in the head injury group lasted longer than in those of the fracture group.

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