몇가지 간질환에 있어 혈중 Neopterin 치의 의의 = Clinical Significance of Serum Neopterin in Some Liver Diseases몇가지 간질환에 있어 혈중 Neopterin 치의 의의

다국어 초록 (Multilingual Abstract)

N/A

다국어 초록 (Multilingual Abstract)

It was recently observed that the hyperimmune response in vitro as in vivo was always accompanied by high levels of neopterin. Indeed in vitro, the stimulation of lymphocytes or macrophages either with viral alloantigens or with chemically modified autologous cells induces a remarkable release of this substance by means of the gamma interferon induction. In the viral infections the increased levels of neopterin could be due to the direct stimulation by the virus on the nucleic acid of the hosts cell (wacher et al ; 1957) Our aim was to verify if during fatty liver or hepatitis, and in cirrhosis of the liver there could be significant variation of serum neopterin levels. We studied 75 patients suffering from hepatic diseases, ranging between 22 and 84 year (mean age 48.96+14.2) and 20 healthy controls homogeneous for sex and age to our patients. The mean values of serum neopterin were 2.17+0.94 ng/ml in patients and 1.59+0.35 ng/ml in the control group. These data was correlated with the mean values of both SGOT and SGPT that were 152.25+278.61 IU/L, 204+405.94 IU/ respectively, and the statistical study showed positive but low correlation coefficient (SGOT:r = 0.28, p<0.05; SGPT:r = 0.30, p<0,05). There was no significant difference of serum neopterin levels between patients with fatty liver and control group (t = 1.057, p>0.05). However, the statistical study showed a significant difference between hepatitis, cirhosis of the liver and the normal control group(p<0.05). Serum neopterin levels and triglycerides were shown to be the best variables for discriminating between the hepatitis and fatty liver patients, neopterin being the more specific of the two. No significant correlation of serum neopterin levels between B hepatitis and non B hepatopathies could be found.