지용성약물에 의한 간세포의 Smooth-surfaced Endoplasmic Reticulum의 형태변화 = Morphologic Changes of Smooth Surfaced Endoplasmic Reticulum of Liver Cell Induced by Fat-Soluble Drugs

국문 초록 (Abstract)

저자는 체중 200∼300gm의 잡종 흰쥐에 phenobarbital을 체중 100gm당 5mg을 증류수에 녹여 복강내로 매일 혹은 격일로 투여하여 얻은 간세포의 미세구조 변화로 요약하면 다음과 같다.
1. Phenobaribital 투여 후 1일내지 2일부터 sER이 증식하기 시작하여 5일및 10일째에 최고도에 달하여 그후 실험종료시까지 지속된다.
2. Glycogen particle은 sER의 증식과는 반비례적으로 phenobarbital투여 후 1∼2일부터 감소하기 시작하여 5∼10일째에는 거의 세포질에서 찾아볼수 없게 된다.
3. sER이 증식하기 시작하면 sER과 rER과의 이행상이 더욱 뚜렷해지며, 세포내 다른 소기관에는 현저한 변화는 없는 것 같다.
4. 이상의 연구성적으로 보아은 약물대사 및 해독작용과 밀접한 관련성이 있는것으로 생각된다.

다국어 초록 (Multilingual Abstract)

The author studied the fine structural changes of rat liver cells induced by phenobarbital. Albino rats, weighing about 200 to 300 Gm., were received intraperitioneal injections of 5mg of phenobarbital per 100 Gm. of body weights daily or on alternative days for 7 times, respectively. Fine structural changes were examined under the electron microscope.
The results obtained were summarized as follow:
1. Proliferation of smooth surfaced endoplasmic reticulum (sER) were observed from 1 to 2 days after injections of phenobarbital and reached to maximum degree after 5 to 10 days, which sustained to the end of the experiment.
2. Glycogen particles were substantially decreased from 1 to 2 days and totally disappeared at 5 to 10 days after phenobarbital injections, respectively.
3. Transformation of rough surfaced endoplasmic reticulum (rER) to sER was prominent with proliferation of sER, but the oher organellar changes were not imptessive.
4. The results suggested sER was intimately related to the drug metabolism and detoxication function of the cells.