폐 효모균증 -2예 보고- = Pulmonary Cryptococcosis -Report of 2 cases-

다국어 초록 (Multilingual Abstract)

Cryptococcus neoformans is a ubiquitous fungus found worldwide, particularly in soil contaminated by pigeon droppings. Pulmonary cryptococcosis occurs rarely in immunocompetent individuals. The risk of cryptococcal infection increases with the degree of immunal compromise, in human immunodeficiency virus infection especially. Pulmonary cryptococcosis is most frequently encountered as asymptomatic single or multiple pulmonary nodules found by routine chest x-ray examination. The diagnosis is most often made in these situations by the histology of the resected lesion. Acute progressive pneumonia may occur, with symptoms of cough, sputum production, fever, and weakness. The clinical picture is not pathognomonic. The yeasts are stained well by any of the special stains for fungi. Treatment is now indicated for all cases given a diagnosis of cryptococcosis, even if the diagnosis has been made by resecton of a solitary, asymptomatic pulmonary nodule.

국문 초록 (Abstract)

효모균은 전 세계적으로 도처에 분포하고 있는 곰팡이로서, 특히 비둘기 배설물에 의해 오염된 토양에 존재한다. 폐의 효모균증은 건강한 사람에게는 잘 발생하지 않으며 면역이 저하된 환자 특히 후천성 면역결핍증 환자에게서 호발한다. 일반적으로 증상이 없이 흉부엑스선상 고립성 또는 다발성 폐결절이 관찰되며, 절제된 조직에서의 병리학적 소견으로 진단된다. 기침이나 객담, 발열 및 무력감 등의 급성폐렴의 증상을 보일 수 있으나 질병특유의 증상은 아니다. 효모균증은 대부분의 곰팡이 염색에 의해 진단되며, 증상이 없는 고립성 폐결절을 포함하여 진단된 모든 효모균증에 있어서 약물치료를 시행한다.

참고문헌 (Reference)

1 "Pulmonary diseases. 6th ed" New York: Lippincott-Raven Publishing Co 1998

2 "Pulmonary cryptococcosis:localized and disseminated infections in 27 patients with AIDS" 21 : 628-33, 1995

3 "Pulmonary cryptococcosis in patients without HIV infection" 115 : 734-40, 1999

4 "Pulmonary cryptococcosis" 7 : 51-5, 1992

5 "Pulmonary cryptococcosis" 16 : 121-8, 1985

6 "Primary pulmonary cryptococcosis" 61 : 39-49, 1971