Aspirin投與가 Rat의 胃粘膜 細胞에 미치는 微細形態學的硏究 = Effect of Aspirin on the Fine Structure of Rat Gastric Mucosal Cells.

다국어 초록 (Multilingual Abstract)

A study was undertaken on rats in order to clarify the gastric mucosal, morphologic response to oral and subcutaneous administration of acetylsalicylic acid(aspirin).
Aspirin was administered orally (oral group) and subcutaneously (subcutaneous group) at does rate of 60 mg per kg of body weight per day to 40 normal rats. On the 1st, 3rd, 7th, and 15th day of administration, in addition to clinical observation, 5 rats each from the both groups were sacrificed and examined macroscopically, histologically and electron-microscopically for the morphological changes of gastric mucosal cells with the following results.
Although the clinical, macroscopic and histological changes were not significant, marked ultrastrastural changes were observed.
Parietal and chief cells were affected most severely by the administration of aspirin ; parietal cells showed increase in the number of SER and intracellular canaliculi, where-as in chief cells fragmentation, luminal dilatation, decrease in the number and structural abnormalities of RER were seen. Relatively mild changes were observed in mucous, mucous neck and basal-granulated cells.
Although the degree of changes was milder than those of oral group, the similar changes were also observed in the subcutaneous group.
From these results, it would be concluded that aspirin injury of gastric mucosa is effected not only by the direct injury to the mucosa but also indirectly by the blood concentration of arpirin.