호흡기 알레르기 환자에서의 쌀겨에 대한 피부반응도 및 특이 IgE 측정 = 호흡기 알레르기 환자에서의 쌀겨에 대한 피부반응도 및 특이 IgE 측정

다국어 초록 (Multilingual Abstract)

To evaluate the allergenic importance of ricebran as a causative allergen in respiratory allergy diseases, skin prick test with ricebran, other cereal grain extracts and housedust mite and ricebran radioimmunoassay were performed in 188 patients with bronchial asthma and /or allergic rhinitis visiting the Allergy Clinic in the Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine from March 1988 to Feb. 1989. 1. The positive rate(>=1+) to the extracts of ricebran on skin prick test was 46.8% in respiratory allergy patients. 2. In comparison to negative responders on skin prick test to ricebran, positive responders on skin prick test(>=2+) were significantly more in young age and students(p=0.01).There were no significant differences in the kinda of used pillows, duration of respiratory symptoms, serum total IgE and total eosinophil counts between two groups. 3. The concurrent positive rates on skin tests were 90.7%(r =0.23) to D. farinae, 96.3%(r=0.36) to threshing mixture and 75.9% (r=0.41) to Tyrophagus putrescentiae in positive responders on skin test to ricebran(>=2+). 4. On the radioimmunoassay for detection of specific IgE to ricebran(rieebran-RIA), 23 cases (29.5%) in 78 cases with positive skin reactivity ( >=21+ ) of ricebran noted positive reaction. 5. The detection rate of ricebran specific IgE were 30.6% in the group of positive skin test to the ricebran and 27.6% in group of negative akin test. There were no specific correlation between wheal size of skin prick test to ricebran and bound radioactivity(%) of ricebran-RIA. 6. The detection rate of ricebran specific IgE were 64.0% in 25 sera with more than 500IU / ml of total serum IgE and 73.6% in 53 sera with less than 500IU / ml. It was suggested that total IgE did not influence to deteet the specific IgE by ricebran- RIA. 7. There were remarkable cross-allergenicities among ricebran, ricehusk, brown rice and barley bran on ricebran-RIA inhibition tests. There was moderate cross allergenicity between ricebran and rice, but no cross allergenicities between ricebran and storage mite(T. putrescentiae). The refore, ricebran aa an inhalant allergen, which shows frequent positive reactions on skin prick test and of which specific IgE are detected in respiratory allergy patients, must be further evaluated carefully on its activities as an offending allergen on respiratory allergic diseases and on its cross allergenicity with allergenic pollens.