Analysis of the Incidence and Clinical Features of Colorectal Nonadenocarcinoma in Korea: A National Cancer Registry-Based Study

다국어 초록 (Multilingual Abstract)

Purpose: Although most colorectal malignancies are adenocarcinomas from mucosa, various types of malignant and benign tumors can develop. Due to extremely low incidence, little research has been conducted. The purpose was to assess incidence and compare it according to demographic factors.Methods: Data from the Korea National Cancer Registry from 2007 to 2016 were used. The crude incidence, age-standard incidence rate (ASR) of colorectal nonadenocarcinomas were calculated.Results: Over 11 years, there were 267,142 patients with colorectal malignancies. The patients of 14,495 (5.43%) were diagnosed with nonadenocarcinoma. The ASR was 2.52 per 100,000 in men and 1.56 in women. Lesions were classified according to histologic categories; neuroendocrine tumor (NET) was the most common malignancy (10,919 [75.33%]). Nonadenocarcinoma was the most common in 40s and 50s (40 to 49 years, 3,530 [24.35%]; 50 to 59 years, 3,991 [27.53%]). Lymphoma was high (54.46%) in patients in teenagers. Proportion of NET decreased with age and that of carcinoma increased with age. Carcinoma, sarcoma, and lymphoma were more common among men and melanoma was more common among women. The most common site was the rectum (11,066 [76.34%]). Lymphoma occurred more frequently in proximal colon. Melanoma, gastrointestinal stromal tumor, and NET occurred mostly in rectum. A total of 10,155 patients (70.06%) were classified as having localized disease.Conclusion: This study is meaningful as it is the first study to examine incidence of colorectal nonadenocarcinoma. Differences in incidence of different lesions based on demographic factors were identified. This study will play a role in cancer prevention and diagnosis projects.

참고문헌 (Reference)

1 Akbulut S, "What is the clinicopathological characteristic of cloacogenic carcinoma outside the anorectal zone?" 58 : 52-55, 2011

2 정은선, "Update on the Proposal for Creating a Guideline for Cancer Registration of the Gastrointestinal Tumors (I-2)" 대한병리학회 46 (46): 443-453, 2012

3 Nahas CS, "Squamous-cell carcinoma of the rectum : a rare but curable tumor" 50 : 1393-1400, 2007

4 Gaston EA, "Squamous-cell carcinoma of the colon and rectum : report of a case" 10 : 435-442, 1967

5 남수민, "Risk Factors for Colorectal Cancer in Korea: A Population-Based Retrospective Cohort Study" 대한대장항문학회 35 (35): 347-356, 2019

6 Konishi T, "Prognosis and risk factors of metastasis in colorectal carcinoids : results of a nationwide registry over 15 years" 56 : 863-868, 2007

7 Sharma B, "Primary diffuse large B-cell lymphoma of the descending colon" 358 : 164-167, 2019

8 Meijer S, "Primary colorectal sarcoma : a retrospective review and prognostic factor study of 50 consecutive patients" 125 : 1163-1168, 1990

9 Hangge PT, "Primary colorectal lymphoma : institutional experience and review of a national database" 62 : 1167-1176, 2019

10 Kim YH, "Primary colon lymphoma in Korea : a KASID(Korean Association for the Study of Intestinal Diseases)Study" 50 : 2243-2247, 2005

11 Son HJ, "Primary T-cell lymphoma of the colon" 12 : 238-241, 1997

12 정규원, "Prediction of Cancer Incidence and Mortality in Korea, 2017" 대한암학회 49 (49): 306-312, 2017

13 Khalid U, "Pathogenesis, diagnosis and management of primary melanoma of the colon" 9 : 14-, 2011

14 Thiels CA, "Outcomes of primary colorectal sarcoma : a National Cancer Data Base(NCDB)review" 21 : 560-568, 2017

15 Ford MM, "Neuroendocrine tumors of the colon and rectum" 60 : 1018-1020, 2017

16 Bernick PE, "Neuroendocrine carcinomas of the colon and rectum" 47 : 163-169, 2004

17 Cuffy M, "Management of less common tumors of the colon, rectum, and anus" 5 : 327-337, 2006

18 Statistics Korea, "Korean Standard Classification of Diseases"

19 Soreide K, "Global epidemiology of gastrointestinal stromal tumours(GIST) : a systematic review of population-based cohort studies" 40 : 39-46, 2016

20 Torre LA, "Global cancer statistics, 2012" 65 : 87-108, 2015

21 Luna-Perez P, "Colorectal sarcoma : analysis of failure patterns" 69 : 36-40, 1998

22 DiSario JA, "Colorectal cancers of rare histologic types compared with adenocarcinomas" 37 : 1277-1280, 1994

23 Liu Z, "Colonic gastrointestinal stromal tumor : a population-based analysis of incidence and survival" 2019 : 3849850-, 2019

24 Yamamoto H, "Clinicopathological features of primary leiomyosarcoma of the gastrointestinal tract following recognition of gastrointestinal stromal tumours" 63 : 194-207, 2013

25 Murray SE, "Clinicopathologic characteristics of colonic carcinoid tumors" 184 : 183-188, 2013

26 Chang SC, "Clinical features and management of primary colonic lymphoma" 45 : 73-77, 2012

27 Ferlay J, "Cancer incidence and mortality patterns in Europe : estimates for 40 countries in 2012" 49 : 1374-1403, 2013

28 Cagir B, "Adenosquamous carcinoma of the colon, rectum, and anus: epidemiology, distribution, and survival characteristics" 42 : 258-263, 1999

29 Kiran RP, "Adenosquamous carcinoma of the colon : a rare tumor" 72 : 754-755, 2006

30 Raja J, "A case of primary melanoma of the transverse colon" 9 : e1803-, 2017