신갈나무 추출물의 안전성 및 항산화성 = Antioxidant and Safety Test of Natural Extract of Quercus mongolica

국문 초록 (Abstract)

본 연구는 폭쇄처리된 신갈나무로부터 유래된 열수추출물의 안전성 및 항산화성 효과에 대해 검토하였다. 안전성시험으로는 세포독성실험, 경구투여 독성시험이 실시되었으며, 신갈나무 폭쇄처리 열수추출물의 항산화성 유무를 확인하기 위해서 실험동물은 일본 Air Logistics사의 4주령 B6C3F1 숫컷 생쥐로 다섯 군(1군 10마리)으로 나누어서 실험을 하였다. 신갈나무 폭쇄처리 열수추출물의 세포독성 및 경구투여 독성시험의 결과로 독성은 관찰되지 않았으며, 신갈나무 폭쇄처리 열수추출물의 투여군에서 과산화물분해효소의 활성이 29% 이상 증가하여 과산화물분해효소의 활성이 유의적으로 인정되었다. 따라서 신갈나무 폭쇄처리 열수추출물은 뛰어난 안전성과 항산화성이 있음을 확인하였다.

다국어 초록 (Multilingual Abstract)

In this study, natural extract of Ouercus mongolica by steaming explosion treatment were tested for antioxidant ac-tivity and safety. To determine the antioxidative properties of the hot water extracts, experiments were carried out by dividing into four groups (10 mice per group) of four-week-old B6C3F1 male mice from Air Logistics, Japan. As safe-ty test, cell viability test, oral toxicity test were done. The activity of peroxidase was increased by more than 29% in the group treated with hydrothermal extract. From 4 kinds of safety tests, toxicity was not observed. From ex-perimental results, natural extract of Ouercus mongolica by steaming explosion treatment showed superb safety and an-tioxidant effect.

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