電子水晶나노 측정장치를 이용한 표면개질된 Ti산화표면의 생물부착 및 생체적합성 실시간 관찰

다국어 초록 (Multilingual Abstract)

Anodization is a promising surface modification technique for materials used in biomedical applications. Biocompatibility is an essential consideration when evaluating a material for its use in biomedical application. Unique behavior of living microorganism is the ability to deposit on various material surfaces. The biocompatibility of diversely modified Titanium oxide surfaces were investigated by measuring the mass of bacteria deposited on the surfaces immersed in stationary distilled water. Two different bacteria were used for the study namely Escherichia coli and Staphylococcus aureus. In this study, the biocompatibility of diversely modified three different Titanium surfaces was analyzed using Electrochemical Quartz Crystal Nanobalance (EQCN). According to our results, electrochemically anodized Ti surfaces exhibited a very good biocompatibility than the other two surfaces.

목차 (Table of Contents)

• ChapterⅠ. Introduction 1
• 1.1 Onerview 1
• 1.1.1 Biocompatibility of long-term implanted devices 1
• 1.1.2 Biocompatibility of short-term implantable devices 2
• 1.2 Anodization 2
• 1.2.1 Anodized titanium 4
• 1.2.2 Environmental impact 5
• 1.2.3 Mechanical considerations 5
• 1.3 Dental implant 6
• 1.3.1 Medical uses 9
• 1.3.2 Biomechanical considerations 11
• ChapterⅡ. Materials and experiment 13
• 2.1 Electrochemical Quartz Crystal Nanobalance 13
• 2.2 Coating Ti on quartz crystal using physical vaopr deposition 17
• 2.3 Preparation of EC Ti oxide using anodization 17
• 2.3.1 Cyclic voltametry 18
• 2.4 Bacteria attachment test 22
• 2.4.1 Escherichia coli 22
• 2.4.2 Staphylococcus aureus 24
• ChapterⅢ. Result and discussion 28
• 3.1 Electrochemical anodization 28
• 3.2 Atomic force microscopy and Scanning electron microscopy 28
• 3.3 X-ray photoelectron spectroscopy depth profile 31
• 3.4 Bacteria attachment test using EQCN 32
• ChapterⅣ. Conclusion 37
• ChapterⅤ. References 38