Proteomics is the study of the "proteome" or the entire protein complement of a genome. It is now well-established that proteomics is far more complex than simply cataloguing all the proteins present in a cell or organism at a given time. Proteomics n...
Proteomics is the study of the "proteome" or the entire protein complement of a genome. It is now well-established that proteomics is far more complex than simply cataloguing all the proteins present in a cell or organism at a given time. Proteomics now includes not only the identification of proteins or the study of protein expression pattern but also the understanding of post-translational processing of proteins or protein-protein interaction, which often result in the alteration of protein stability, localization and/or function. Here we briefly summarize how proteomics has been evolved during the last decade and review a few crucial techniques widely used in the proteomic studies, such as 2-DE and mass spectrometry. Moreover, we discuss the applications of proteomic tools in related research areas and its potentials in drug discovery and the study of diseases.