Influence of postnatal Angelicae gigantis radix herb-acupuncture on prenatal noise stress-induced NOS expression in the offspring rats

국문 초록 (Abstract)

목적 : 당귀는 전통적으로 학습과 기억능력 증진 및 각종 질병치료에 우수한 효과가 있는 것으로 알려져 있다. 본 연구에서는 이러한 인삼약침이 소음스트레스가 유발된 태아쥐의 해마 및 시상하부에서 nitric oxide synthase에 미치는 영향을 관찰하였다.
방법 : 당귀약침이 소음스트레스에 미치는 영향을 연구하기 위하여 태아기에 소음스트레스를 유발하고 생후 4주후 7일간 당귀약침을 투여한 후 NADPH-d 조직화학법을 시행하였다.
결과 : 1. 소음스트레스는 태아쥐의 해마 및 시상하부에서 NOS 발현이 유의하게 증가하였다.
2. 당귀약침은 해마 CA1에서만 소음스트레스에 의해서 증가된 NOS 발현을 유의하게 억제하였다.
3. 당귀약침은 시상하부 PVN, DMH 및 LHA에서 소음스트레스에 의해서 증가된 NOS 발현을 유의하게 억제하였다.
결론 : 본 연구를 통하여 당귀약침이 소음스트레스가 유발된 태아쥐의 해마 및 시상하부에서 증가된 NOS 발현을 유의하게 억제시켜 태아의 스트레스 자극에 당귀약침치료가 유의한 효과가 있음을 확인하였다.

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