고혈압성 임신에 관한 임상적 연구 : 안지오텐신 주입시험과 태반의 역활 1. Angiotensin infusion test and role of the placenta = A Clinical Study on the Pregnancy Induced Hypertension

다국어 초록 (Multilingual Abstract)

In gravid women who are destined to develop pregnancy-induced hypertension(PIH), normal pregnancy associated refractories to the pressor effects of administered angiotensin Ⅱ is lost several weeks before the onset of hypertension. From a study of the determinants of A- Ⅱ pressor responsiveness in normal gravid women, it appears likely that the loss of resistense to A-11 is partialy unrelated to plasma renin activity or plasma A-Ⅱ levels.
Recently the role of PGA about the renin-angiotensin-aldosterone system and of 5α-DHP on the restoration of refractoriness to the pressor effect of A-11 was reported in relation to the pathophysiologic alterations in the development of pregnancy-induced hypertension.
It is, therefore, the purpose of the present study to determine the response of normal pregnant, toxemic, and postpartum patients to the "angiotensin infusion test" based on the assumption that patients with increased endogenous level of angiotensin(renovascular hypertension) will require greater doses of the exogenous angiotensin to achieve a given pressor response.