土茯笭을 이용한 Rats의 水銀中毒 解毒에 관한 硏究 = Bibliographic Study on the Therapy of Gastric Cancerby Intergrated Orienral and Western Medicine

국문 초록 (Abstract)

산업화 사회의 등장으로나타난 중금속 중독은 이미 세상을 경악시키고 있다. 이에 대해 의약학계에서 많은 연구들이 이루어지고 있으나 한의학적 접근이 아직 이루어지지 못하고 있는 실정이다. 이에 수은중독에 대해 한의학적으로 해독효과가 있다는 土茯笭을 이용하여 쥐를 통한 그 해독효과를 실험해 보았다. 조직내 수은함량, 조직내 MT함량, 혈액학적 변화, 장기조직 검사에서 유의한 결과가 밝혀졌으며 구체적인 해독의 기전과 성분은 알 수 없으나 토복령의 전해질 수분대사에 의한 작용인 것으로 사료된다.

다국어 초록 (Multilingual Abstract)

This study was performed to find out the antitoxic effects of Smilacis Glabrae aganist Mercuric Chloride poisoning. The experimental rats were divided into 4 groups such as mercury alone treatment group, and three dose groups of Smilacis Glabrae. Each group was administered with different dose of Smilacis Glabrae such as 15mg, 30mg, 45mg/kg wet weight in pallets for four weeds. Mercuric chloride was administered by 0.7mg/kg body weight rat per day.
After giving the challenge dose, mercury, metallothionein concentration and histopathological changes were determined.
The results were summarized as follows:
1. The simultaneously administration of Smilacis Glabrae and mercury significantly more decreased mercury concentration in liver compared to the administration of mercury only(P〈0.05).
2. The simultaneously administration of Smilacis Glabrae and mercury significantly more increased renal metallothionein concentration in liver compared to the administration of mercury only(P〈0.05).
3. When kidney and liver tissues were obsreved with as optical microscope, slight changes were visible in those tissues.