Sulfa 劑 投與가 白鼠營養에 미치는 影響 : 體成分 變動에 對하여 = A Study on Nutritional Effect of the Feeding of Sulfadimethoxine on Change in Chemical Composition of Some Abdominal Organs.

다국어 초록 (Multilingual Abstract)

This study was carried out to observe some of the nutritional effect by feeding sulfadimethoxine with or without thiamine supplement in rats. The male albino rats from a pure strain, weighing 205-246g, were used for the experimental animals. They were divided into three diet groups; the standard, the high carbohydrate and the high protein diet group. A half part of the each group of the animals was fed with sulfa drug, 150㎎/㎏ sulfadimethoxine, prior to feeding each morning meal once a day, whereas therest of them was fed with same amount of the sulfa drug supplemented with 1.5㎎/㎏ of thiamine HCl.
The animals maintained with above-mentioned dietary conditions were sacrificed on the 4th hour. 1st, 3rd, 7th and 15th day after feeding. The nitrogen, lipid and cholesterol contents in the liver, kidney, small intestine and blood, and the hemoglobin and hematocrit values in the blood were measured.
The results obtained are summarized as follows;
Ⅰ. The effect of dietary difference:
1. The nitrogen content in the kidney was increased by feeding the high carbohydrate and the high protein diet compared with the standard diet.
2. The lipid contents in the liver and the plasma were increased by feeding the high carbohydrate and the high protein diet compared with the standard diet, whereas the lipid contents in the kidney and the small intestine were decreased during feeding the high carbohydrate diet.
3. The cholesterol contents in the liver and the plasma were more increased by feeding the high carbohydrate diet than the standard diet.
Ⅱ. The effect of feeding the sulfa drug.
1. The nitrogen content in the kidney was more increased by feeding the standard diet with the sulfa drug than the control group, whereas the animals fed the high carbohydrate diet with the sulfa drug showed decreasing tendency from 3 to 15 days after feeding.
2. The lipid contents in each organ were significantly increased on 4th hour after feeding the standard diet with the sulfa drug, compared with their control group, and the content in each organ was generally increased by feeding the high carbohydrate with the sulfa drug.
3. The cholesterol contents in the small intestine and the plasma were generally increased by feeding each diet with the sulfa drug, compared with their control group.
4. The changing of the hemoglobin and hematocrit value were shown similar tendency by feeding the sulfa drug compared with their control group.
Ⅲ. The effect of feeding the sulfa drug with thiamine HCl.
1. The lipid contents in the liver and the plasma were generally increased by administering the sulfa drug with thiamine HCl, compared with their control group, whereas the content in the kidney was decreased.
2. The cholesterol content in the kidney was shown increasing tendency by administering the sulfa drug with thiamine HCl, compared with their control group, whereas the content in the plasma showed increasing tendency.
As above results, dietary conditions and administration of the sulfa drug had shown significant influence on the change of the chemical composition of some abdominal organs, while simultaneous administration of the sulfa drug supplemented with thiamine HCl had shown less effect on them.

목차 (Table of Contents)

• Ⅰ. 緖論
• Ⅱ. 實驗材料 및 方法
• A. 食餌
• B. 實驗動物
• C. 食餌와 藥劑投與方法
• D. 試料採取
• E. 測定方法
• Ⅲ. 實驗成績
• A. 臟器內 窒素含量
• B. 臟器內 脂質含量
• C. 臟器內 cholesterol 含量
• D. Hb 과 Ht 値
• Ⅳ. 總括 및 考察
• Ⅴ. 結論
• Reference