Self-assembly of Glyco-based Polymers for Biomedical Applications

다국어 초록 (Multilingual Abstract)

The biologics such as proteins and nucleic acids are attracting attention as innovative next-generation pharmaceutical products. We have developed various bio-inspired nanocarriers based on nanogel engineering, proteoliposome engineering and exosome engineering for biologics delivery in drug delivery system (DDS) and tissue engineering. A new methodology (nanogel tectonics) was proposed for constructing functional gels by controlling the association of self-assembled nanogels as building blocks, and apply them as biomaterials. Polymer vesicles represent potentially suitable compartments for nanofactories that can accumulate at disease sites in the body, where encapsulated enzymes would convert toxic materials into harmless compounds or transform inert prodrugs into cytotoxic compounds. We found a polymeric vesicle of glyco-based polymer (poly (propylene oxide) (PPO)) with an intrinsically permeable bilayer membrane as new enzyme nanoreactors. A new approach for enzyme prodrug cancer therapy have been proposed using bio-transporting nanofactories.