A new humulene sesqulterpene, 5-hydroxyzerumbone (5-hydroxy-2E,6E,9E-humulatrien-8-one) (1) and a known compound, zerumboneoxlde (2) were isolated from the rhizomes of Ziagiber zerumbet (Zinglberraceae), and found to Inhibit lipopolysaccharlde-Induced...
A new humulene sesqulterpene, 5-hydroxyzerumbone (5-hydroxy-2E,6E,9E-humulatrien-8-one) (1) and a known compound, zerumboneoxlde (2) were isolated from the rhizomes of Ziagiber zerumbet (Zinglberraceae), and found to Inhibit lipopolysaccharlde-Induced nitric oxide production in murlne macrophage RAW 264.7 cells with IC_(50) values of 14.1 and 23.5㎛, respectlvely, by bloassay-guided fractlonation (positive control: N^(ω) monomethyl-L-arginine, IC_(50)=21.3㎛). The structure of 1 was determined by spectroscopic methods Including 1D and 2D-NMR.