Pancreatic Exocrine Insufficiency-Questionnaire (PEI-Q)의 활용 = The Use of Pancreatic Exocrine Insufficiency-Questionnaire (PEI-Q)

국문 초록 (Abstract)

만성췌장염의 합병증 중 하나인 외분비 기능부전은 환자의 삶의 질을 저하시키는 주요한 요인 중 하나이며, 이에 대한 적극적인 진단 및 치료가 필요하다. 여러 검사법들이 사용되고 있으나 국내에서의 정확도가 낮고 모니터링에 용이하지 않아 활용도가 낮으며, 많은 비용이 소요된다는 단점이 존재한다. 외국에서는 유용성이 검증된 PEI-Q는 이러한 단점들을 보완할 수 있을 것으로 기대되는 검사법 중 하나로, 국내에서의 유용성 검증이 필요하나 임상에서 적극적으로 활용한다면 비교적 적은 비용으로도 환자의 높은 순응도를 유도할 수 있을 것으로 예상된다. 추후 이에 대한 다 기관 연구와 협의가 필요하다.

다국어 초록 (Multilingual Abstract)

Chronic pancreatitis is a non-reversible, progressive inflammatory disease of the pancreas that is caused by repeated inflammation. It is characterized by morphological changes in the parenchyma and main pancreatic duct as pancreatic tissue is damaged and fibrosis progresses. These changes can lead to exocrine and endocrine dysfunction in patients with chronic pancreatitis, with major complications including pain, endocrine or exocrine insufficiency, and increased risk of pancreatic cancer. Of these, pancreatic exocrine insufficiency (PEI) is a state of malabsorption in which more than 15 g of fat is excreted per day. It can be diagnosed and assessed using several methods, but these methods are currently difficult to use in Korea and have low compliance, making them low utility. Recently, the PEI-questionnaire (PEI-Q) was developed to diagnose and assess patients’ exocrine insufficiency. It has been validated in foreign countries and has the potential to be used as a tool for diagnosing exocrine insufficiency with simple questions. This paper will review the diagnostic methods for existing exocrine insufficiency and the usefulness and utilization of the PEI-Q.