Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus

다국어 초록 (Multilingual Abstract)

Virus-like particles (VLPs) composed of the truncatedcapsid protein of swine hepatitis E virus (HEV) weredeveloped and immune responses of mice immunized withthe VLPs were evaluated. IgG titers specific for the capsidprotein of swine HEV were significantly higher for allgroups of mice immunized with the VLPs than those of thenegative control mice. Splenocytes from mice immunizedwith the VLPs also produced significantly greater quantitiesof interferon (IFN)-γ than interleukin (IL)-4 and IL-10.
These newly developed swine HEV VLPs have the capacity to induce antigen-specific antibody and IFN-γ production in immunized mice.

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