폐암의 세포진단: 진단의 정확도와 함정 = Cytological Diagnosis of Lung Cancer: The Diagnostic Accuracy and Pitfalls

다국어 초록 (Multilingual Abstract)

The role of respiratory cytology is to detect and classify pulmonary disease, with an emphasis of neoplastic disease, so that proper therapy can be instituted. As in many branches of cytology, the recognition of malignancy in the cells obtained from the respiratory tract is more straightforward than identifying the type of tumor cell. It is important to accurately determine the true cytopathological cell type in cases of primary lung cancer and to know the accuracy of the diagnosis achieved by the cytological procedures. The well differentiated tumors have characteristic cytoplasmic and nuclear abnormalities that enable physicians to firmly categorize these lesions, as in squamous cell or adenocarcinoma, but some moderately and most poorly differentiated tumors show few distinctive features. This article reviews the malignant and reactive pulmonary cytologic findings and we also report on some of their pitfalls and the cytologic criteria.

참고문헌 (Reference)

1 조은윤, "폐암 진단방법으로서 객담검사의 유용성" 대한세포병리학회 15 (15): 75-80, 2004

2 최영희, "세침흡인 세포검사에서 폐의 소세포암종과 샘암종의 감별진단" 대한세포병리학회 17 (17): 120-125, 2006

3 Gupta RK, "Value of sputum cytology in the diagnosis and typing of bronchogenic carcinomas, excluding adenocarcinomas" 26 : 645-648, 1982

4 Nunez V, "Tracheobronchial cytology after laryngectomy for carcinoma of larynx. II. benign atypias" 10 : 38-48, 1966

5 Berg J, "The value of cytology in the diagnostics of lung cancer" 113 : 208-212, 2005

6 Delgado PI, "Small cell carcinoma versus other lung malignancies: diagnosis by fine-needle aspiration cytology" 90 : 279-285, 2000

7 Roby TJ, "Reliability of a quantitative interpretation of sputum cytology slides" 34 : 140-146, 1990

8 Edwards SL, "Preoperative histological classification of primary lung cancer: accuracy of diagnosis and use of the non-small cell category" 53 : 537-540, 2000

9 Raz DJ, "Misclassification of bronchioloalveolar carcinoma with cytologic diagnosis of lung cancer" 1 : 943-948, 2006

10 Wiatrowska BA, "Large-cell neuroendocrine carcinoma of the lung: proposed criteria for cytologic diagnosis" 24 : 58-64, 2001

11 Bruderman I, "Immunocytochemical characterization of lung tumors in fine-needle aspiration. The use of cytokeratin monoclonal antibodies for the differential diagnosis of squamous cell carcinoma and adenocarcinoma" 66 : 1817-1827, 1990

12 MacDonald LL, "Fine-needle aspiration biopsy of bronchioloalveolar carcinoma" 93 : 29-34, 2001

13 Dahlstrom JE, "Fine needle aspiration cytology of pulmonary lesions: a reliable diagnostic test" 33 : 13-16, 2001

14 Halloush RA, "Fine needle aspiration cytology of lung lesions: a clinicopathological and cytopathological review of 150 cases with emphasis on the relation between the number of passes and the incidence of pneumothorax" 18 : 44-51, 2007

15 Kim WS, "Fine needle aspiration cytology of inflammatory pseudotumor of the lung: report of a case misdiagnosed as adenocarcinoma" 10 : 145-149, 1999

16 Johnston WW, "Fine needle aspiration biopsy versus sputum and bronchial material in the diagnosis of lung cancer. A comparative study of 168 patients" 32 : 641-646, 1988

17 Ng AB, "Factors significant in the diagnostic accuracy of lung cytology in bronchial washing and sputum samples. I. Bronchial washings" 27 : 391-396, 1983

18 Park IA, "Evaluation of cytopathologic diagnosis of lung carcinoma" 2 : 20-27, 1991

19 Steinmann G, "Effect of methods of sample taking on the cytologic diagnosis of lung tumors" 22 : 425-430, 1978

20 Auger M, "Differentiating cytological features of bronchioloalveolar carcinoma from adenocarcinoma of the lung in fine-needle aspirations: a statistical analysis of 27 cases" 16 : 253-257, 1997

21 Kakinuma H, "Diagnostic findings of bronchial brush cytology for pulmonary large cell neuroendocrine carcinomas: comparison with poorly differentiated adenocarcinomas, squamous cell carcinomas, and small cell carcinomas" 99 : 247-254, 2003

22 Crapanzano JP, "Diagnostic dilemmas in pulmonary cytology" 93 : 364-375, 2001

23 Payne CR, "Diagnostic accuracy of cytology and biopsy in primary bronchial carcinoma" 34 : 773-778, 1981

24 Kim JM, "Diagnostic Sensitivity of sputum and bronchial washing cytology in bronchogenic carcinomas confirmed by bronchoscopic biopsy" 12 : 17-23, 2001

25 Truong LD, "Diagnosis and typing of lung carcinomas by cytopathologic methods. A review of 108 cases" 29 : 379-384, 1985

26 Erozan YS, "Cytopathologic diagnosis of pulmonary neoplasms in sputum and bronchoscopic specimens" 3 : 188-195, 1986

27 de Masi D, "Cytomorphologic criteria of bronchioloalveolar cell cancer" 44 (44): 610-611, 1990

28 Albright CD, "Cytomorphologic changes in splitcourse radiation-treated bronchogenic carcinomas" 4 : 9-13, 1988

29 Renshaw AA, "Cytology Committee, College of American Pathologists. Distinguishing small cell carcinoma from non-small cell carcinoma of the lung: correlating cytologic features and performance in the College of American Pathologists Non-Gynecologic Cytology Program" 129 : 619-623, 2005

30 Renshaw AA, "Cytology Committee, College of American Pathologists. Distinguishing carcinoid tumor from small cell carcinoma of the lung: correlating cytologic features and performance in the College of American Pathologists Non-Gynecologic Cytology Program" 129 : 614-618, 2005

31 Zusman-Harach SB, "Cytological features of non-small cell carcinomas of the lung in fine needle aspirates" 44 : 997-1002, 1991

32 Hiroshima K, "Cytological characteristics of pulmonary large cell neuroendocrine carcinoma" 48 : 331-337, 2005

33 Bavikatty NR, "Cytologic features of small-cell carcinoma on ThinPrep" 29 : 8-12, 2003

34 Johnston WW, "Cytologic diagnosis of lung cancer. principles and problems" 181 : 1-36, 1986

35 Saleh HA, "Bronchioloalveolar carcinoma: diagnostic pitfalls and immuno-cytochemical contribution" 18 : 301-306, 1998

36 Park CK, "Analysis of transthoracic fine needle aspiration cytologic diagnoses of pulmonary nodules" 6 : 133-139, 1995